This study explores the experiences of telemedicine and online case management for addiction during the COVID-19 pandemic. In this cross-sectional study, data were collected from 80 outpatients undergoing treatment for addiction by purposive sampling. The collected data were then statistically analyzed. The analysis revealed 81.9% of patients were satisfied with telemedicine, but 9.1% were very dissatisfied with their experience of telemedicine. Concerns were raised by 63.7% of patients that telemedicine consultations or remote psychotherapy might not accurately reflect their clinical issues or their problems might be overlooked by the mental health professionals. In terms of online case management, 91.5% of patients were satisfied with the online case management they used, and 88.6% thought that it was helpful to their treatment for substance use disorder. The majority of patients gave positive feedback about telemedicine and online case management for substance use disorder during COVID-19 pandemic period. However, there were also some potential challenges and predicaments in implementing telemedicine care and online case management, e.g. how to protect patient privacy, how to improve the interface design for telemedicine platforms, how to enhance professional competency of telemedicine among healthcare providers, and how to optimize online case management procedures.