本人（1991）曾提出一解釋致癌病變之合理劑量反應模式，該模式以Weibull分 佈為基礎引入藥理動力參數，惟此一模式僅及於特定之藥理動力反應過程，並未考 慮將此一過程廣義化，本研究乃針對此加以修正，並藉以推導出廣義之致癌病變劑 量反應模式。

　　　　　Lin (1991) provided a plausible Dose-Response Model which is based on Weibull distribution with parameters of Pharmacokinetic reaction of carcimogenesis. However, it didn't consider the general case of pharamacokinetic reaction. In this study, we attempt to generalize the pharmacokinetic parameter and modify this Dose-Response Model.