致癌風險之定量推估--動物數據為例__臺灣人文及社會科學引文索引資料庫

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題名：	致癌風險之定量推估--動物數據為例
書刊名：	中國統計學報
作者：	林正祥／陳章榮
出版日期：	1995
卷期：	33:2
頁次：	頁249-274
主題關鍵詞：	風險評估；累加風險；信賴區間估計值；多段模式；有效劑量；致癌物質混合物；Risk assessment；Additive risk；Confidence limit estimate；Multistage model；Effective dose；Mixture
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:27

近年來由於環境品質的日益惡化，各國政府、工業界與學術界，均非常重視一門新興的學問-風險評估，作為對危險物質 (包括致癌物質) 管理之決策。本研究之目的，係利用風險評估之原理，探討利用動物的數據，來定量推估人類所能承受之風險，並列舉實倒說明致癌混合物質環境標準之訂定，而此亦可推廣為其他毒性物質環境標準之設定。

以文找文

The purpose of this article is to discuss the procedures and issues of quantitative estimation of human risk using animal bioassay data. Attention is given to the method involved in extrapolating from high experimental dose levels to low environmental exposure levels. Also, an example of quantitative estimation of joint risk from a mixture of hexachlorobenzene and chlorobenzene is given.

以文找文

期刊論文
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會議論文
1.	Armitage, P.、Doll, R.(1961)。Stochastic models for carcinogenesis。The Fourth Berkeley Symposium on Mathematical Statistics and Probability。Berkeley, California：University of California Press。19-38。
2.	Felton, R. P.、Chen, J. J.(1988)。Evaluation of a dose-response model incorporation pharmacokinetics。The Annual meeting of the American Statistical Association。American Statistical Association。

研究報告
1.	Zeise, L.、Wilson, R.、Crouch, E. A. C.(1986)。The dose response relationships for carcinogens: a review。Cambridge, Massachusetts：Harvard University。
2.	National Research Council(1983)。Drinking Water and Health。Washington, DC：National Academy Press。
3.	National Toxicology Program(1982)。Carcinogenesis Bioassay Experimental and Status Report。Research Triangle Park, NC：National Toxicology Program。

圖書
1.	Gart, J. J.、Krewski, D.、Lee, P. N.、Tarone, R. E.、Wahrendorf, J.(1986)。Statistical Methods in Cancer Research, Vol 3--The Design and Analysis of Long-Term Animal Experiments。Lyon：International Agency for Research on Cancer。
2.	Finney, D. J.(1971)。Probit analysis。Cambridge University Press。

其他
1.	Howe, R. B.，Crump, K. S.(1982)。GLOBAL82: a computer program to extrapolate quantal animal toxicity data to low-doses(41USC252C3)。

圖書論文
1.	Silvers, A.、Crump, K. S.(1989)。Examination of risk estimation models。Hankbook of Carcinogen Testing。Park Ridge, New Jersey：Noyes Publication。
2.	Crump, K. S.、Howe, R. B.(1983)。A review of methods for calculating confidence limits in low-dose extrapolation。Toxicological Risk Assessment。CRC Press。
3.	Krewski, D. A.、Van Ryzin, J. A.(1981)。Dose response models for quantal toxicity data。Statistics and Related Topics。Amsterdam：North-Holland。

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