This paper develops a model for deciding whether to route an air shipm ent through a hub or directly to its destination. The logistic cost functions for two yptes of shipping routes ae formulated by considering relevant costs in shipping process and then compared to make the optimal route choice. The model shows how the time value of shipments, route flows and spatial distribution of origin, destination and hub airports affect the shipping costs and route choices. For each link with specific flow and distance, there are procedures in the model to find the optimal type of aircraft which yields the minimunm cost. The paper also identifies critical route flows which decide the optimal routing for freights shipped between origin and destination airports. The sensitivity analysis of the model shows that the routing via a cargo hub will be more necessary when the time value of an air shipment raises.