目的：情感性疾患與葡萄糖代謝的關係，很早被注意。憂鬱症的病患有葡萄糖不耐受現象，躁症時葡萄糖代謝情形則較無定論。本文即針對急性躁期葡萄糖代謝加以研究。方法：依DSM-111-R連續收集32位無糖尿病史的急性躁症住院病患，施以口服葡萄糖耐受試驗(OGTT)。結果：葡萄糖不耐受率為50%，而且至少有69% 的個案呈現一過性現象。比較葡萄糖耐受異常與正常兩組間各種因素，除了年齡、肥胖可能有差異外(P值各為0.08、0.07)， 其餘性別、鋰鹽初次使用或長久使用、鋰鹽治療長短、鋰鹽濃度、糖尿病家族史、情感性疾病家族史，皆未達統計上顯著差異。但在上述因素暫時不變下，個案仍呈現高比例一過性現象，推測可能與急性躁症狀態相關。結論：本研究指出急性躁病患者有高比率之一過性血糖不耐受現象，此現象可能與鋰鹽的使用無關。

　　　　　Objective: Glucose intolerance has been associated with depression for several decades. However, the actual relationship between acute mania and glucose metabolism is still uncertain. Method: We evaluated the data of thirty-two patients who were consecutively admitted to acute psychiatric wards and fulfilled the DSM-III-R criteria for acute mania. Result: Fifty percent (16/32) of these patients showed glucose intolerance as reveled by 100gm Oral Glucose Tolerance Test (OGTT). At least 69% (11-16) of case showed transient intolerance. There were no statistically significant differences in the demographic factors between the OGTT normal and abnormal groups. But the higher rates of aged and obese patients in the OGTT intolerance group may need further investigation. We strongly suspected that transient glucose intolerance was due to acute mania because of the temporally similar demographic data of these patients. Conclusion: The high rate of transient glucose intolerance was noted in acute manic patients and it did not appear to be associated with lithium use.