The purpose of this paper was to investigate the applications of Systematic Instructional Design technique to the courses of Library Instruction. The study was carried out first analyzing the meaning of Library Instruction and its importance in the general education in universities as well as proposing the required contents for these Library Instruction courses. The meanings, procedures, and methods of the Systematic Instructional Design were then introduced to illustrate how to apply them to the design of Library Instruction courses in order that the contents of courses were more complete and the scope of the courses could be achieved more effectively.