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題名:多氯戴奧辛類化學物質之暴露與毒性
書刊名:中華公共衛生雜誌
作者:張火炎李俊璋桂椿雄郭育良 引用關係
作者(外文):Chang, Ho-yuanLee, Ching-changKuei, Chun-hsiungGuo, Yueliang Leon
出版日期:1999
卷期:18:1
頁次:頁13-27
主題關鍵詞:戴奧辛夫喃多氯聯苯暴露毒性DioxinsFuransPCBsToxicityExposure
原始連結:連回原系統網址new window
相關次數:
  • 被引用次數被引用次數:期刊(3) 博士論文(0) 專書(1) 專書論文(0)
  • 排除自我引用排除自我引用:3
  • 共同引用共同引用:0
  • 點閱點閱:51
     由於多氯戴奧辛(以下稱戴奧辛),與其化學結構類似的化學物質,如多氯夫喃(以下稱夫喃)與多氯聯苯等,被發現在動物實驗中有極強的致癌性及對環境的衝擊,在公共衛生上引起很大的關切。其中2,3,7,8-四氯戴奧辛甚至在已開發國家中被稱作『世紀之毒』。這篇研究就其發生源、環境流佈與各種環境介質之暴露量、重大人類的暴露族群、戴奧辛的吸收、代謝、與排出暨戴奧辛的毒性作用作一綜合介紹。第一次世界大戰以來工業需求甚大的多氯聯苯已逐漸因其對環境與生態的衝擊被多國禁用。待解決的是殘留的多氯聯苯如何處置,對於環境的衝擊才會較小,而毒性較大的 戴奧辛與夫喃卻是含氯物質因高熱或處理過程產生之不純物,很難避免,未來公共衛生的挑戰即是致力於改善工作流程,減少戴奧辛類化合物之產生,發展分解戴奧辛類化合物之生物或工程技術上加以努力。
     Due to the carcinogenicity and the considerable impact on our environment and ecosystems, polychlorinated dibenzo-para-dioxins (Dioxins) and their structurally similar compounds such as polychlorinated dibenzo-para-furans (Furans) and polychlorinated biphenyls (PCBs) have become concerns to public health. Among them, 2,3,7,8 tetra-dioxin has been called the 烢oison of the century?because it is the strongest hepatocarcinogen. The sources, exposure levels in various environmental media and corresponding e nvironmental fates, number of significant episodes, and toxicities of these compounds were extensively reviewed. We concluded that, residual PCBs, further efforts should focus on reducing the harmful effects. However, for dioxins and furans, the challenges are to improve the technology to decrease the production of these impurities within the manufacturing process, and to develop the biotechnology to decompose these persistent compounds.
期刊論文
1.Fishbein, L.(1987)。Health-risk estimates for 2,3,7,8-tetrachlorodibenzo-p-dioxin: An overview。Toxicol lnd Health,3,91-134。  new window
2.Gochfeld, M.、Gallo, M.、Kahn, P.(1988)。Dioxin exposure and health。N Eng J Med,85,907-912。  new window
3.Rappe, C.(1992)。Sources of PCDDs and PCDFs。Chemosphere,25,41-44。  new window
4.Landers, J. P.、Bunce, N. J.(1991)。The Ah receptor and the mechanism of dioxin toxicity。Biochem J,276,273-287。  new window
5.Poiger, H.、Buser, H. R.、Weber, H.、Zweifel, U.、Schlatter, C.(1982)。Structure elucidation of mammalian TCDD-metabolites。Experientia,38,484-486。  new window
6.Skene, S. A.、Dewhurst, I. C.、Greenberg, M.(1989)。Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans: the risks to human health。Hum Toxicol,8,173-204。  new window
7.Hay, A.(1978)。Dioxin source is 'safe'。Nature,274,526。  new window
8.McConnell, E.、Huff, J.、Hejtmancik, M.、Peters, A.、Persing, R.(199110)。Toxicology and carcinogenesis studies of two grades of pentachlorophenol in B6C3F1 mice。Fundam Appl Toxicol,17(3),519-532。  new window
9.Fiedler, H.、Hutzinger, O.、Timms, C.(1990)。Dioxins: Sources of environmental load and human exposure。Toxicol Environ Chem,29,157-234。  new window
10.Linder, G.、Jenkins, A.、McCormack, J.、Adrian, R.(1990)。Dioxins and furans in emissions from medical waste incinerators。Chemosphere,20,1793-1800。  new window
11.Marklund, S.、Andersson, R.、Tysklind, M.(1990)。Emissions of PGDDs and PGDFs in gasoline and diesel fueled cars。Chemosphere,20,553-561。  new window
12.Hagenmaier, H.、Dawidowsky, N.、Weberruss, U.(1990)。Emission of polyhalogenated dibenzodioxins and dibenzofurans from combustion-engines。Organohalogen Compounds,2,329-334。  new window
13.Riss, A.、Scheidl, K.(1990)。Statutory and research action in Austria。Organohalogen Compounds,4,51-56。  new window
14.Rappe, C.(1992)。Sources of PCDDs and PCDFs。Chemosphere,25,41-44。  new window
15.Harrad, S.、Jones, K.(1992)。A source inventory and budget for chlorinated dioxins and furans in the United Kingdom environment。Sci Total Environ,126,89-107。  new window
16.Czuczwa, J.、Hites, R.(1986)。Airborne dioxins and dibenzofurans: Sources and fates。Environ Sci Technol,20,195-200。  new window
17.Koester, C.、Hites, R.(1992)。Photodegradation of polychlorinated dioxins and dibenzofurans adsorbed to fly ash。Environ Sci Technol,26,502-507。  new window
18.Connett, P.、Webster, T.(1987)。An estimation of the relative human exposure to 2,3,7,8-TCDD emissions via inhalation and ingestion of cow's milk。Chemosphere,16,2079-2084。  new window
19.Webster, T.、Connett, P.(1990)。The use of bioconcentration factors in estimating the 2,3,7,8-TCDD content of cow's milk。Chemosphere,20,779-786。  new window
20.McLachlan, M.、Hutzinger, O.(1990)。Accumulation of organochlorine compounds in agricultural food chains。Organohalogen Compounds,1,479-484。  new window
21.Schartz, P.、Jacobson, S.、Fein, G.(1983)。Lake Michigan fish consumption as a source of polychlorinated biphenyl in human cord serum,maternal serum and milk。Am J Public Heaith,73,293-296。  new window
22.Jacobson, J. L.、Humphrey, H. E.、Jacobson, S. W.(1989)。Determinants of polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyl trichloroethane (DDT) levels in the sera of young children。Am J Public Health,79,1401-1404。  new window
23.Ohgami, T.、Nonaka, S.、Murayama, F.(1989)。A comparative study of polychlorinated biphenyls (PCBs) and polychlorinated quaterphenyls (PCQ) concentrations in subcutaneous fat tissue,blood and hair of patients with Yusho and normal control in Nagaski prefecture。Fukuoka Acta Medica,80,307-312。  new window
24.Skaare, J. U.、Tuveng, J. M.、Sande, H. A.(1988)。Organochlorine pesticides,and polychlorinated biphenyls in maternal adipose tissue, blood, milk, and cord blood from mothers and their infants living in Norway。Arch Environ Contam Toxicol,17,55-63。  new window
25.Kreiss, K.(1985)。Studies on populations exposed to polychlorinated biphenyls。Environ Health Perspect,60,193-199。  new window
26.Centers for Disease Control(1988)。Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to Humans--Seveso, Italy。MMWR,37,733-736。  new window
27.Centers for Disease Control(1989)。Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans--Seveso, Italy。JAMA,261,831-832。  new window
28.Centers for Disease Control(1990)。Preliminary Report: dioxin levels of exposed population in Seveso, Italy。JAMA,263,1023-1025。  new window
29.Barinaga, M.(1989)。Agent Orange: Congress impatient for answers。Science,245,249-250。  new window
30.Levy, C. J.(1988)。Agent Orange exposure and post-traumatic stress disorder。J Nerv Ment Dis,176,242-245。  new window
31.Centers for Disease Control(1987)。Serum dioxin in Vietnam-era veterns-preliminary report。MMWR,36,470-475。  new window
32.Centers for Disease Control(1988)。Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in air force health study participants-preliminary report。MMWR,37,309-311。  new window
33.Bond, G. G.、McLaren, E. A.、Lipps, T. E.、Cook, R. R.(1989)。Update of mortality among chemical workers with potential exposure to the higher chlorinated dioxins。J Occup Med,31,121-123。  new window
34.Centers for Disease Control(1987)。Results of a pilot study of health effects due to 2,3,7,8-tetrachlorodibenzodioxin contamination--Missouri。MMWR,36,470-475。  new window
35.Stern, A. H.、Munshi, A. A.、Goodman, A. K.(1989)。Potential exposure levels and health effects of neighborhood exposure to a municipal incinerator bottom ash landfill。Arch Environ Health,44,40-48。  new window
36.Stehr-Green, P. A.、Andrews, J. S.、Webb, K. B.、Hoffmann, R. E.、Schramm, W. F.(1988)。An overview of the Missouri USA dioxin studies,1982。Arch Environ Health,43,174-177。  new window
37.Webb, K.、Evans, R. G.、Stehr, P.、Ayres, S. M.(1987)。Pilot study on health effects of environmental 2,3,7,8-TCDD in Missouri。Am J Ind Med,11,685-692。  new window
38.Kimbrough, R. D.、Falk, H.、Stehr, P.、Fries, G.(1984)。Health implications of 2,3,7,8-tetratchlorodibenzodioxin (TCDD) contamination of residential soil。J Toxicol Environ Health,14,47-93。  new window
39.Taki, I.、Hisanaga, S.、Amagagase, Y.(1969)。Report on Yusho pregnant women and their fetuses。Fukuoka Acta Med,68,471-474。  new window
40.Masuda, Y.(1985)。Health status of Japanese and Taiwanese after exposure to contaminated rice oil。Environ Health Perspect,60,321-325。  new window
41.Chen, P. H.、Chang, K. T.、Lu, Y. D.(1981)。Polychlorinated biphenyls and polychlorinated dibenzofurans in the toxic rice bran oil that caused PCB poisoning in Taichung。Bull Environ Contain Toxicol,26,489-495。  new window
42.Phillips, D. L.、Smith, A. B.、Burse, V. W.(1989)。Half-life of polychlorinated biphenyls in occupationally exposed workers。Arch Environ Health,44,351-354。  new window
43.Schecter, A. J.、Ryan, J. J.、Constable, J. D.(1986)。Chlorinated dibenzo-p-dioxin and dibenzofuran levels in human adipose tissue and milk samples from the north and south of Vietnam。Chemosphere,15,1613-1620。  new window
44.Czuczwa, J. M.、Niessen, F.、Hites, R. A.(1985)。Historical record of polychlorinated dibenzo-p-dioxins and dibenzofurans in Swiss lake sediments。Chemosphere,14,1175-1179。  new window
45.Pirkle, J. L.、Wolfe, W. H.、Patterson, D. G.(1989)。Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam veterans of operation ranch hand。J Tox Environ Health,27,165-171。  new window
46.Bertazzi, P. A.、Zocchetti, G.、Pesatori, A. C.、Guercilena, S.、Senarico, M.、Rodice, L.(1989)。Ten-year mortality study of the population involved in the Seveso incident in 1976。Am J Epidemiol,129,1187-1200。  new window
47.Patterson, D. G.、Fingerhut, M. A.、Roberts, D. R.(1989)。Levels of polychlorinated dibenzo-p- dioxins (PCDD's) and dibenzofurans (PCDF's) in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin。Am J Ind Med,16,135-146。  new window
48.Fingerhut, M. A.、Halperin, W. E.、Marlow, D. A.(1991)。Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin。N Eng J Med,324,212-218。  new window
49.Zober, A.、Messerer, P.、Huber, P.(1990)。Thirty-four-year mortality follow-up of basf employees exposed to 2,3,7,8-tcdd after the 1953 accident。Int Arch Occ Environ Health,62,139-150。  new window
50.Mocarelli, P.、Patterson, D. G. Jr.、Marocchi, A.(1990)。Pilot study (phase II) for determining polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) levels in serum of Seveso, Italy residents collected at the time of exposure: future plans。Chemosphere,20,967-974。  new window
51.Zober, A.、Messerer, P.、Huber, P.(1990)。Thirty-four-year mortality follow-up of BASF employees exposed to 2,3,7,8-TCDD after the 1953 accident。Int Arch Occ Environ Health,62,139-157。  new window
52.Manz, A.、Berger, J.、Dwyer, J. H.(1991)。Cancer mortality among workers in chemical plant contaminated with dioxin。Lancet,338,959-964。  new window
53.May, G.(1982)。Chloracne from the accidental production of tetrachlorobenzodioxin。Br J Ind Med,39,128-135。  new window
54.Moses, M.、Prioleau, P. G.(1985)。Cutaneous histologic findings in chemical workers with and without chloracne with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin。J Am Acad Dermatol,12,497-506。  new window
55.Barbieri, S.、Pirovano, C.、Scarlato, G.、Tarchini, P.、Zappa, A.、Maranzana, M.(1988)。Long-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the peripheral nervous system: Clinical and neurophysiological controlled study on subjects with chloracne from the Seveso area。Neuroepidemiology,7,29-37。  new window
56.Safe, S.(1984)。Polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs): Biochemistry, toxicology, and mechanism of action。CRC Crit Rev Toxicol,13,319-395。  new window
57.Alvares, A. P.、Fischbein, A.、Anderson, K. E.、Kappas, A.(1977)。Alteration in drug metabolism in workers exposed to polychlorinated biphenyls。Clin Pharm Ther,22,140。  new window
58.Fries, C. F.(1985)。The PBB episode in Michigan: An overall appraisal。CRC Crit Rev Toxicol,16,105-156。  new window
59.Safe, S.(1987)。Determination of 2,3,7,8-TCDD toxic equivalent factors (TEFs): Support for the use of the in vitro AHH induction assay。Chemosphere,16,791-802。  new window
60.Cook, J. C.、Caido, K. W.、Greenlee, W. F.(1987)。Ah receptor: relevance of mechanistic studies to human risk assessment。Environ Health Perspect,76,71-77。  new window
61.Hardell, L.、Eriksson, M.、Lenner, P.、Lundgren, E.(1981)。Malignant Lymphoma and Phenoxy Acids: A Case Control Study。Br J Cancer,43,169-176。  new window
62.Hardell, L.、Eriksson, M.(1988)。The association between soft-tissue sarcomas and exposure to phenoxyacetic acids: A new case control study。Cancer,62,652。  new window
63.Eriksson, M.、Hardell, L.、Adam, H.(1990)。Exposure to dioxins as a risk factor for soft tissue sarcoma: A population-based case-control study。J Nat Cancer Inst,82,486-490。  new window
64.Fingerhut, M. A.、Halperin, W. E.、Honchar, P. A.、Smith, A. B.、Groth, D. H.、Russel, W. O.(1984)。An evaluation of reports of dioxin exposure and soft tissue sarcoma pathology among chemical workers in the United States。Scand J Work Environ Health,10,299-303。  new window
65.Wiklund, K.、Dich, J.、Holme, L. E.(1988)。Soft tissue sarcoma risk in Swedish licensed pesticide applicators。J Occup Med,30,801-804。  new window
66.Woods, J. S.、Polissar, L.、Severson, R. K.、Heuser, L. S.、Kulander, B. G.(1987)。Soft tissue sarcoma and non-Hodgkin's lymphoma in relation to phenoxyherbicide and chlorinated phenol exposure in western Washington。J Natl Cancer Inst,78,899-910。  new window
67.Bertazzi, A.、Pesatori, A. G.、Gonsonni, D.、Tironi, A.、Landi, M. T.、Zocchetti, C.(1993)。Cancer incidence in a population accidentally exposed to 2, 3, 7, 8-tetracMorodibenzo-para-dioxin。Epidemiol,4,398-406。  new window
68.Silbergeld, E. K.、Mattison, D. R.(1987)。Experimental and clinical studies on the reproductive toxicology of 2, 3, 7, 8-tetracMorodibenzo-p-dioxin。Am J Ind Med,11,131-144。  new window
69.Mastroiacovo, P.、Spagnolo, A.、Marni, E.、Meazza, L.、Bertollini, R.、Segni, G.(1988)。Birth defects in the Seveso area (Italy) after TCDD contaminadon。JAMA,259,1668-1672。  new window
70.Mocarelli, P.、Brambilla, P.、Gerthoux, P. M.、Patterson, D. G. Jr.、Needham, L. L.(1996)。Change in sex ratio with exposure to dioxin。Lancet,348,409。  new window
71.Calvert, G. M.、Hornung, R. W.、Sweeney, M. H.(1992)。Hepatic and Gastrointestinal Effects in an Occupational Cohort Exposed to 2,3,7,8-Tetrachlorodibenzo-para-dioxin。JAMA,267,2209-2214。  new window
72.Calvert, G. M.、Sweeney, M. H.、Morris, J. A.(1992)。Evaluation of chronic bronchitis,chronic obstructive pulmonary disease, and ventilatory function among workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin。Am Rev Respir Dis,144,1302-1306。  new window
73.Sweeney, M. H.、Fingerhut, M. A.、Arezzo, J. C.、Hornung, R. W.、Connally, L. B.(1993)。Peripheral neuropathy after occupational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)。Am J Ind Med,23,845-858。  new window
74.Kuratsune, M.、Yoshimura, Y.、Matsuzaka, J.、Yamaguchi, A.(1972)。Epidemiological study of Yusho, a poisoning caused by ingestion of dee oil contaminated with commercial brand of polychlorinated biphenyls。Environ Health Perspect,1,119-128。  new window
75.Nakayama, J.、Hori, Y.、Toshitani, S.、Asahi, M.(1997)。Dermatological findings in the annual examination of the patients with Yusho in 1995-1996。Fukuoka Acta Medica,88,236-239。  new window
76.Wong, K. C.、Hwang, M. Y.(1981)。Children born to PCB poisoning mothers。Clin Med (Taipei),7,83。  new window
77.Harada, M.(1976)。Intrauterine poisoning: clinical and epidemiological studies of the problem。Bull Inst Const Med, Kumamoto Univ,25,1-60。  new window
78.Chen, Y. C.、Guo, Y. L.、Hsu, C. C.、Rogan, W. J.(1992)。Cognitive development of Yu-Cheng ('oil-disease')children prenatally exposed to heat-degraded PCBs。JAMA,268,3213-3218。  new window
79.Eadon, G.、Kaminsky, L.、Silkworth, J.(1986)。Calculation of 2, 3, 7, 8-TCDD equivalent concentrations of complex environmental contaminant mixtures。Environ Health Perspect,70,221-227。  new window
80.Safe, S.(1990)。Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs),dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs)。Crit Rev Toxicol,21,219-238。  new window
會議論文
1.Bremmer, H.、Sein, A.(1991)。Sources of dioxins in the Netherlands。Dioxin '91。Research Triangle Park, NC。  new window
2.Ryan, J. J.、Hsu, C. C.、Guo, Y. L.(1993)。Exposure of children whose mothers suffered from Yu-Cheng poisoning to polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs)。13th International Symposium on Chlorinated Dioxins and Related Compounds,46。  new window
3.Guo, Y. L.、Lin, C. J.、Yao, W. J.、Hsu, C. C.(1992)。Musculoskeletal changes in Yu-Cheng children compared with their matched controls。12th International Symposium on Chlorinated Dioxins and Related Compounds。Tampere, Finland。  new window
4.Guo, Y. L.、Lai, T. J.、Ju, S. H.、Chen, Y. C.、Hsu, C. C.(1993)。Sexual developments and biological findings in Yu-Cheng children。13th International Symposium on Chlorinated Dioxins and Related Compounds。Vienna, Austria。47。  new window
圖書
1.USEPA(1992)。Estimating Exposure to Dioxin-Like Compounds: Draft。Cincinnati, Oh。  new window
2.Work On Waste USA(19901025)。Waste Not。Canton, NY。  new window
圖書論文
1.Voogt, P. D. E.、Brinkman, U. A. T.(1989)。Production, properties and usage of polychlorinated biphenyls。Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products。Amsterdam:Elsevier。  new window
2.Rejinders, P.、Brasseur, S.(1992)。Xenobiotic induced hormonal and associated developmental disorder in marine organisms and related effects in humans: An overview。Chemically-Induced Alterations in Sexual and Functional Development: The Wildlife/Human Connection。Princeton:Princeton Scientific Publishing Co.。  new window
3.Kuratsune, M.(1989)。Yusho, with reference to Yu-Cheng。Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products。Amsterdam:Elsevier。  new window
4.Rogan, W.(1989)。Yu-Cheng。Halogenated Biphenyls, Terphenyls, Naphthalenes, Dibenzodioxins and Related Products。Amsterdam:Elsevier。  new window
5.Barry, C.、Webster, T.(1994)。Overview: the dioxin debate。Dioxins & Health。New York:Plenum Press。  new window
6.Humphrey, H. E.(1988)。Chemical contaminants in the Great Lakes: the human health aspect。Toxic contaminants and ecosystem health: a Great Lake focus。New York:Wiley。  new window
7.Olson, J. R.(1994)。Pharmacokinetics of Dioxin and Related Chemicals。Dioxins and Health。New York:Plenum Press。  new window
8.National Cancer Institute(1987)。Dioxins and dibenzofurans in carcinogenesis,1980-1986。Oncology overview。Washington, DC:International Cancer Data Bank, National Cancer Institute。  new window
 
 
 
 
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