With the development of economic globalization, metropolitan area or global city region has increasingly become the strategic space unit of the world political, economic, and social development. In as early as the 1950 s, many interstate metropolitan areas emerged in the United States, and a number of effective cross-border governance methods and strategies were formed. This paper mainly analyzes and summarizes the cross-border governance measures and experience of interstate metropolitan areas in the United States, so as to provide useful reference for the cross-border governance in the Yangtze River Delta Metropolitan Area, Pearl River Delta Metropolitan Area, and Beijing-Tianjin-Tangshan Metropolitan Area in China.