中樞免疫失衡與認知功能障礙：聚焦TNFα的作用__臺灣人文及社會科學引文索引資料庫

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題名：	中樞免疫失衡與認知功能障礙：聚焦TNFα的作用
書刊名：	心理科學進展
作者：	張瑜／林文娟／王瑋文
出版日期：	2017
卷期：	2017(12)
頁次：	2036-2042
主題關鍵詞：	內穩態；應激；突觸可塑性；認知功能；TNFα；Homeostasis；Tumor necrosis factor；Stress；Synaptic plasticity；Cognitive function
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:6

中樞免疫對于神經系統內穩態的維持意義重大。免疫活性分子TNFα及其受體系統參與神經發育、突觸可塑性和認知功能調節;其表達異常,無論過度或者不足都可能導致對腦功能和行為的不良影響。應激,尤其是發育早期應激可能通過影響中樞TNFα的動態發展過程從而造成其功能的持續改變,并與后期免疫相關的心理病理發生密切相關。未來研究需拓展中樞免疫與認知功能障礙之間的因果聯系,建立基于免疫調節的疾病防治新策略。

以文找文

Central immune activities exert important roles in maintaining homeostatic process of central nervous system. It has shown that the dynamically balance of brain TNFα participates in the regulation of neurodevelopment, synaptic plasticity and cognitive function by its receptor signaling, while imbalance of TNFα signaling, no matter excessive or insufficient, can result in adverse effects on brain function and behavior. Stress, especially early stress, may disturb the dynamic development process of TNFα signaling and thus cause lasting alterations of its expression and receptor function, which strongly linked to the increasing incidences of immune-related psychopathological disorders in late life. Future studies are needed to deepen the understanding of causal relationships between central immunity and cognitive dysfunction, and establish new strategies for disease prevention and treatment based on immunoregulation.

以文找文

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