Based on desirable difficulty theory and disfluency theory, disfluency prosessing can benefit learning. However according to cognitive load theory, disfluency perceived during learning may bring extra cognitive load thus impair learning outcome. A2(perceptual fluency: fluency, disfluency) ×3(background information: relevant, irrelevant, control) between subject experiment was conducted to investigate how cognitive load(valued by relevant level of background information) and perceptual fluency interact when learning meaningful text. The results showed that, the main effect of two variables was significant, which turned out that subjects learned better when presented fluent material, and relevant background information led to better performance than the other two conditions. The interaction effect was significant: Under fluency condition, subjects who were provided relevant background information learned better than subjects provided irrelevant information or none(control), and there was no significant difference between the latter two. Under disfluency condition, there was no significant difference between different levels of background information. These results indicated that for meaningful material learning, enhancing the perceptual fluency and providing relevant background information should be more desirable ways, which is consistent with the theory of cognitive load.