In order to investigate the influence mechanism of alexithymia on college students’ mobile addiction tendency, a total of 1224 college students were investigated by using the Toronto Alexithymia Scale, Mobile Phone Addiction Tendency Scale, UCLA Loneliness Scale and Mindful Attention Awareness Scale. The results were as follows: 1) College students’ alexithymia, mobile addiction tendency and loneliness had significant correlations with each other. 2) Loneliness played a partial mediating role in the relationship between alexithymia and mobile addiction tendency. 3) Mindfulness significantly moderated the influence of loneliness on college students’ mobile phone addiction tendency. Mindfulness and loneliness formed a moderated mediating model between alexithymia and college students’ mobile phone addiction tendency.