This paper reviews the origin and evolution of information science,sorts out the development of international information science and domestic information science,and clarifies the essence and characteristics of information science and information work.The paper focuses on the "change" and "not change" of information science and information work in the era of big data.The "change" includes that the analysis object goes deep from information into data;the research object returns from information to intelligence,the processing level upgrades from "analysis" to "research",and the theories and methods of related disciplines should be introduced.The "not change" includes the requirement and standard of "broad,fast,precise,accurate",the role definition of "ears,eyes,staff",the function definition of decision support,and the function definition of strategic planning.The conclusion is that the historical mission,fundamental task,the object of research or work,and the boundary of subject or work should not be changed.On the contrary,the contents,methods,tools,technologies,mechanism,and mode of research or work should only be changed.