[Purpose/significance] It is push forward that healthy develop of information science study with Chinese Characteristic and to be building theoretical system,for learn form foreign countries and draw on their success experience in innovation and development developing information science.[Method/process] thesis have been overall sum up the historical survey and research progress at main domain of developing information science’s theory and apply in 50 year,be utilize methods of historical retrospect and comparative analyze.[Result/conclusion] It is think that innovation breakthroughs of research achievement of information science has been gained in three respects into important question establish at subject,amended to basic assumption of theoretical system and it’s theory be closely combined to practice with compare scripture information science in west countries,to be expanded information science’s research category and application value in very great degree.