The article starts with a preliminary analysis of the COVID-19 epidemic and its related factors in American cities,and discusses the relationship between the built environment and the people living in it.It is proposed that in studying the relationship between the epidemic situation and the built environment,epistemology should be emphasized,meaning that the study of the characteristics of the built environment and the characteristics of the people living in it should be both included,and special attention should be paid to the impacts of the residents’ socioeconomic status and lifestyle on the epidemic situation,rather than limited to the built environmental issues.From a methodological point of view,evidence-based practice focusing on practical evidence can be used,which may better fit the nature of the COVID-19 epidemic.