衝動性對不同成癮行為發展的調控及其神經機制__臺灣人文及社會科學引文索引資料庫

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題名：	衝動性對不同成癮行為發展的調控及其神經機制
書刊名：	心理科學進展
作者：	嚴萬森／張冉冉／劉蘇姣
作者(外文)：	Yan, Wansen／Zhang, Ranran／Liu, Sujiao
出版日期：	2016
卷期：	2016(2)
頁次：	159-172
主題關鍵詞：	成癮疾患；衝動性；抑制控制；尼古丁依賴；網絡遊戲成癮；Addiction；Impulsivity；Inhibitory control；Nicotine dependence；Internet gaming disorder
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(1) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:1 共同引用:0 點閱:8

近年來越來越多的研究證據提示,個體衝動性在成癮疾患發生發展機制中具有關鍵作用,可能成為成癮行為的潛在易感標記以及早期識別和干預的重要靶點,但衝動性對不同成癮行為變化發展的調控機制尚不明確。項目擬綜合跨成癮譜系比較、縱向追蹤設計、衝動行為干預等研究途徑,採用人格測量、神經認知、神經影像等技術,首先比較尼古丁依賴者與網絡遊戲成癮者的衝動性結構及其在前額葉–紋狀體環路的結構功能改變;然後採用混合分組設計篩選出具有高低衝動性的非成癮青少年進行連續追蹤研究,考察衝動性對尼古丁依賴與網絡遊戲成癮的預測效力;並採用認知行為訓練,對吸煙成癮者與網絡遊戲成癮者進行衝動干預,考察行為干預對衝動性水平及前額葉–紋狀體環路功能的改變,以及對不同成癮行為發展的抑制後效。旨在探索衝動性作為成癮的潛在易感標記及干預靶點的效力。

以文找文

Mounting evidence has demonstrated that impulsivity could be a potential biomarker that plays a crucial role in the development of addictive behaviors, thus impulsivity is considered a possible treatment target for early intervention of addiction. Nevertheless, it remains unclear how the mechanisms underlying the trajectories of impulsivity are involved in drug addiction and non-drug addiction. This project aims to identify the neural mechanisms of impulsivity in both nicotine dependence and internet gaming disorder by combining a direct comparison of drug and non-drug addictive behaviors with longitudinal studies and a cognitive-behavioral intervention study, using neurocognitive tasks and neuroimaging techniques. Firstly, nicotine-dependent individuals and internet gaming addicts would be tested on a series of behavioral tasks of impulsivity as well as in fronto-striatal brain systems using both structured and functional magnetic resonance imaging(f MRI) with a 3T Philips Trio MRI. Then we will move on to investigate the predictive role of impulsivity for nicotine dependence and internet gaming disorder through a 2 to 3 year follow-up study with a large sample of non-addicted adolescents consisting of two groups with either high- or lowlevels of impulsivity. Thirdly, a study of 6 to 12 month cognitive behavioral intervention would be conducted on nicotine-dependent individuals and internet gaming addicts to explore the possible effects of reducing impulsivity level on the exacerbation of addictive behaviors. And this study will also evaluate the effects of continuous behavioral training on brain functions in fronto-striatal brain systems through f MRI tests. Totally, these studies should be helpful for shedding light on the possible efficacy of impulsivity as a potential biomarker and treatment target for addictive disorders.

以文找文

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其他
1.	Young, K. S.(2009)。Internet addiction test，http://netaddiction.com/internet-addiction-test/。

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