抑郁的多基因遺傳基礎__臺灣人文及社會科學引文索引資料庫

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題名：	抑郁的多基因遺傳基礎
書刊名：	心理科學進展
作者：	曹衍淼／王美萍／曹叢／張文新
作者(外文)：	Cao, Yanmiao／Wang, Meiping／Cao, Cong／Zhang, Wenxin
出版日期：	2016
卷期：	2016(4)
頁次：	525-535
主題關鍵詞：	抑郁；多基因遺傳；內表型；性別差異；Depression；Polygenic；Endophenotypes；Gender difference
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:2

抑郁具有復雜的、非孟德爾式的多基因遺傳模式,但是目前多數抑郁的遺傳研究集中於考察單個候選基因,不能全面揭示遺傳因素的作用機制。近年來,多基因遺傳得分研究和基因-基因交互研究分別為抑郁的多基因累加效應和交互效應提供了新的證據。多基因不僅直接影響抑郁,還通過與環境因素的交互作用影響抑郁的發生發展,並且這一復雜交互作用存在性別差異。抑郁的內表型研究發現多基因可能通過認知因素、人格、壓力荷爾蒙等間接影響個體的抑郁水平。未來研究應更加關注多基因與多種環境因素如何相互作用影響抑郁,探索多基因遺傳機制的性別差異,考察多基因對抑郁影響隨年齡的發展動態變化。

以文找文

Depression has highly complicated polygenic underpinnings that do not follow the law of Mendelian inheritance. However, existing research on the genetic mechanism of depression has primarily focused on the effects of single candidate genes. Recent studies using the method of polygenic risk scores and the gene by gene interactions approach have provided new evidence respectively for the existence of both additive genetic effects and interactive genetic effects on depression. These studies demonstrated that multi- genes interact with environmental factors in their effects on the etiology of depression, and gender has a strong influence on these interactions. It is assumed that the effects of multi-genes on depression would be possibly mediated by the specific endophenotypes, such as cognitive factors, personality and stress hormone. Future research in this realm should pay greater attention to the interactions between multi-genes and multi-environments, gender differences in the polygenic underpinnings and the dynamic changes in polygenic effects over development.

以文找文

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學位論文
1.	Allison, A. L.(2013)。A multi-gene by environment perspective of ADHD symptomatology in young children(博士論文)。University of New Orleans。

圖書
1.	Lerner, R. M.、Zhang, W. X.(2011)。Concepts and theories of human development。Beijing：Peking University Press。
2.	American Psychiatric Association(2013)。Diagnostic and statistical manual of mental disorders。Washington, DC：American Psychiatric Association。
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