Mao Zedong was the leader of first generation of Chinese communist party, and also played a key role in the build-up of the Chinese communist regime. In modern history of China, Mao Zedong was one of modern personages who had great powerful influence, and Maoism, succeeding Marxism-Leninism, is an ideology that is believed in and worshipped by many people in China and even in the world. Therefore, to make a fundamental study of Mao Zedong’s march to Marxist road is to help to understand the birth of Chinese communism, and also to be aware of the modern Chinese intelligentsia’s portrait of mind of saving the country and people from perdition. Firstly, this paper starts to state that, from the background of modern Chinese history, the situations of theory and practice faced by the Chinese intelligentsia were difficult and in a dilemma for saving the country. Until the “ October Revolution” of Russia in 1917 and “ May Fourth Movement” in 1919, many Chinese intelligentsia started to march to the road of Marxism, even made a point of that only Marxism-Leninism could “ rebuild China ” because it provided the weapons of theory and practice. Under this historical background, through more complex path, only then Mao Zedong marched to the road of Marxism. In conclusion, the author points out that communism could be rooted in Chinese land not only because of historical background, but also because of one of the characteristics of Confucianism’s model of thought, that is the characteristic of “ the culture─intellectualistic approach.” The modern Chinese intelligentsia totally inherited this characteristic unconsciously, and, as a intelligentsia, Mao Zedong did the same.