This article further investigates the thought about the manifestation of wisdom in practice in Mencius, continuing the study about intellect in Lun Yu. The word “intellect” appears a lot in Lun Yu, and 25 of which are the equivalent of the word “wisdom”, while the word “intellect” appears 114 times in Mencius, but only two of them are equivalent to “wisdom.” We can already see in Mencius the distinction between the two words, like the way it is now. In this article, we analyze the two appearances of “intellect” as equivalent to “wisdom” and the 32 appearances of the word “wisdom” in Mencius. First, it is pointed out that “wisdom” generally means “intelligence,” “sapience.” Secondly, by juxtaposing the two types of moral characters-the men of wisdom and the men of jen-we can see the homology between the thoughts about the “manifestation of wisdom in practice” respectively in Lun Yu and Mencius as well as the idea of “manifesting wisdom in jen.” Moreover, knowing the fact that “wisdom” being named as one of the four morals with “jen”, “yi”, and “li”, while defining “wisdom” and the essence of wisdom by “Telling right from wrong” and “seeing that jen and yi are not removable,” we can see the essence and innovativeness of the thought about wisdom in Mencius. Furthermore, although the telling of right from wrong is a gift that we are born with, we cannot maintain the manifestation of wisdom in practice without “expansion” and “preservation.” Finally, it is concluded that the “meaning and value of the manifestation of wisdom in practice” is: while emphasizing “jen” as the primary moral, it appreciates the supporting function of the moral of wisdom, and for the first time in history it relates “conscience” to the “manifestation of wisdom” in practice, which directs morality and ethics to introversion and transcendence.