Emperor Ming and Emperor Zhang were the famous rulers in the Eastern Han Dynasty, and they usually were recognized as "Ming-Zhang zhi zhi" (the Flourishing Age of Emperor Ming and Emperor Zhang). In the Chinese historical records, it's traditionally considered that the period of Emperor Ming and Emperor Zhang was the golden age in the Eastern Han Dynasty, and could be competed with the period of Emperor Wen and Emperor Jing in the Western Han Dynasty. Moreover, many historians usually emphasized the differences of individual characters and administrative measures between Emperor Ming and Emperor Zhang. These studies revealed how Emperor Ming and Emperor Zhang made their empires more stable and how different they were. However, these similarity between Emperor Ming and Emperor Zhang. Therefore, these studies were not enough to comprehend Emperor Ming and Emperor Zhang. To comprehend the period of Emperor Ming and Emperor Zhang in depth, the study tries to focus on the relationship between Emperor Zhang and his relatives of the Ma clan and the Dou clan, and tries to explain why the emperor relied on his relatives by marriage. From the study, it's very conspicuous that Emperor Ming and Emperor Zhang continued to use the policies of Emperor Kuang-wu who centralized state power and suspected the officials, these emperors' brothers, and the local powerful clans. From above reasons, the empress's families became the only one in whom the emperors could trust. It explains why these emperors' relatives by marriage could get the political power again in the Eastern Han Dynasty. In short, the strong partnership between Emperor Ming, Emperor Zhang and their empress' families finally led the Eastern Han Empire to go downhill.