As the advance in medical technology, critical patients with ventilator-support after good medical care, have became stable and are able to prolong their survival; but there is still an average of 31% critical patients could not be weaned and become long-term ventilator-dependent patients.The prognosis of ventilator-dependent patients is not ideal. There is a high rate of hospitalization and mortality for them, and decreased daily activities resulting in poor quality of life. As well as the majority of those patients will have depression, anxiety, low self-esteem and other psychological problems, and even unconsciousness, their limbs are rigid and physical activity are totally dependent. Moreover, the long hospital staying consumes many health care resources, but also results in economic, physical, psychological and social stresses on caregivers and families.Some of the patients have the chance of weaning from ventilators, but there are still risks of respiratory failure if extubated. If we help the patient to wean from ventilator in best condition, and then adopt the concept of hospice care opportunely, it can help these patients to reduce unnecessary suffering, but also their families the economic and multilateral loading, and even pass away with dignity and quality of life.We would like to introduce a case of end-stage senile dementia who had long-term intubated with ventilator support, after giving management of the airway hygiene and respiratory training, we tried to extubate, then the patient was weaned from ventilator successfully for 2 months. We also got an identical agreement with his family members, about the "DNR" (Do Not Resuscitate) consent on the recurrence of respiratory failure for the patient. Therefore, the patient could be pass away naturally and peacefully, and his families could be relieved from much unnecessary suffering and burden. We shared this case for caring this kind of patients and promoting the concept of hospice care in the future.