The related research of “Music and the Sign” has close relationship with “music concept’s multidimensional characteristic”. This paper adopts music and the sign as the topic of research. “What is music” is the prime object that to be focused and deliberated. The term of music was evolved from Musiké in Hellenistic times, through Musica that generally used in the medieval times, till today we use the terminology such as Musik in Germen, Music in English, Musique in French, and Musica in Italian. Although these terms represent different language, they are all come from the same root. By analyzing and understanding this, the multiple concept of “Music” that lies in different space and time, and different social environment’s music philosophers, theorists, and practitioner, are very worth of investigating. In particular, since the latter half of the twentieth century the music research has been inspired and influenced by linguistic theories and methods, the sign become essential to understand the basic concepts of music. Furthermore, before the section “Comprehend of music sign”, this article will first discuss “Is music a system of sign?” and to clarify how the sign becoming the basic concepts of understanding the nature of music. As for the intention of using the question “Is music a international language?” as an ending in this essay, is mainly to stress on the a opinion that to consider music as a language, or even a international language is not certainly right. It is because that although the similarity between music and language is surely existent, in their importance of structure’s component elements, they are vastly different.