Big data is referring to the large and complicated data sets. As the development of internet and information technology, the amount of the data generated by people grows everyday in incredible scale. Therefore, the acquisition, analysis, and application of the data had become the focus of all kinds of industries to advance their advantages and to promote the business. In the field of education, big data also made impact on current and future teaching and learning activities. The paper aims to explore the application of big data in twelve-year basic education. First, it explains the definition and development of big data. Secondly, it analyzes the application of big data in twelve-year basic education by probing into the five aspects including policy implementation, school governance, curriculum development, instruction, and learning. Finally, it offers four suggestions of big data in twelve-year basic education, including sufficing related statutory and flexible supplementary regulations, laying stress equally upon the openness of data and the protection of privacy, integrating the existed data and new systematic information, innovating the manpower cultivation and the thinking among leadership.