In the aftermath of a devastating earthquake, emergency management agencies need to provide adequate Emergency Medical Services for initial treatment and delivery of a large number of injuries. Disaster impact software systems, such as TELES (Taiwan Earthquake Loss Estimation System) and EMIC 2.0 (Emergency Management Information Cloud) developed by National Center for Research on Earthquake Engineering (NCREE) and National Fire Agency (NFA) respectively, enable emergency planners and first responders to provide preparation and response information before and during disasters. In order to integrate the previous research with the aforementioned two systems automatically, so the MD-EMS system can be optimized, clouded, and visualized towards further development. It is also anticipated that after the calculation, the system can provide intranet decision-support information and internet disaster communication announcement. Therefore, in this study, the system consists of four main modules: (1) data collection; (2) temporal/geospatial analysis and fitness (3) simulation (4) output analysis and visualization. This study uses a large-scale application example caused by tectonic fault activity to illustrate the use of the system and demonstrate its improved novel functions including triggering system activation through SMS, interconnecting with various service platforms to update the database, collecting real-time empirical data for correction calculations, considering the impact of post-earthquake resources and dynamic visualization for disaster communication, etc.