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題名:長期規律運動對腹部脂肪分佈與瘦身蛋白的影響
作者:曹德弘 引用關係
作者(外文):Tsao,Te-Hung
校院名稱:國立臺灣師範大學
系所名稱:體育研究所
指導教授:謝伸裕
學位類別:博士
出版日期:2001
主題關鍵詞:長期規律運動瘦身蛋白腹部脂肪分佈磁共振造影法long-term regular exerciseleptinabdominal fat distributionmagnetic resonance imaging (MRI)
原始連結:連回原系統網址new window
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  • 被引用次數被引用次數:期刊(2) 博士論文(1) 專書(0) 專書論文(0)
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瘦身蛋白由脂肪組織分泌,在動物的研究,它具有生溫 (thermogensis)、增加身體活動、抑制食慾,進而降低體脂肪之效果。在人體的研究中,血液中的瘦身蛋白隨著體脂肪的多寡而增減。本研究目的以磁共振造影 (magnetic resonance imaging) 來測量三組不同長期規律運動者 (慢跑、游泳、重量訓練,每組各12位) 和一般坐式生活者 (12位受試者) 腹部脂肪體積分佈的差異;各組腹部脂肪體積分佈與瘦身蛋白的關係;各組瘦身蛋白與胰島素、睪固酮的關係。結果發現,在各組體脂肪百分比均未達顯著差異的情況下:各組之間的腹部皮下脂肪體積與腹部脂肪總體積未達顯著差異;在腹部內臟脂肪體積,慢跑組顯著低於控制組與游泳組 (慢跑組 0.40 + 0.27,游泳組0.95 + 0.46,重量訓練組0.66 + 0.26,控制組0.85 + 0.33公升,P< 0.05)。慢跑、游泳、重量訓練與控制組之間血液中瘦身蛋白 (1.64 + 0.62,2.51 + 0.73,2.38 + 1.76,2.30 + 1.80 µg/L)、胰島素 (13.51 + 5.17,17.15 + 4.42,17.22 + 12.93,15.45 + 6.13 ng/ml) 和睪固酮的濃度 (7.05 + 1.63,5.58 + 1.41,6.06 + 1.13,6.16 + 2.34 ng/ml) 均未達顯著差異。各組的瘦身蛋白與腹部皮下脂肪體積與腹部脂肪總體積達顯著相關;在瘦身蛋白與腹部內臟脂肪體積之間關係,當腹部內臟脂肪體積除以腹部脂肪總體積之比值為4組中較小時 (慢跑組0.18,重量訓練組0.21),瘦身蛋白與腹部內臟脂肪體積達顯著相關 (分別為0.89,0.72,P< 0.05);當該項比值為4組中較大時 (游泳組0.26,控制組0.28),瘦身蛋白與腹部內臟脂肪體積未達顯著相關。三組長期規律運動者的瘦身蛋白與胰島素、睪固酮之間沒有顯著相關。結論:長期規律運動有助於維持與降低體脂肪,長期規律慢跑可顯著地降低內臟脂肪體積。由本研究腹部脂肪體積分佈與瘦身蛋白的關係得知:腹部脂肪組織體積是決定瘦身蛋白與腹部脂肪組織關係的因子之一。有關長期規律運動者腹部內臟脂肪體積與腹部脂肪總體積的比值變化和瘦身蛋白的關係,與一般人的比較則須進一步探討。
Leptin is exclusively secreted by adipose tissue. Rodent studies have demonstrated that leptin can affect thermogenesis, increase physical activity, inhibit appetite and decrease body fat. In humans, circulating leptin levels correlate closely with body fat content. Purpose: This study examined the differences in the distribution of abdominal fat among three groups of individuals who engaged in long-term regular exercise (runners, R; swimmers, S; and weight lifters, W; 12 males in each group) and a sedentary group (control, C; 12males). The relationships between abdominal fat distribution, fasting leptin, insulin and testosterone were also studied. Results: There were no significant differences among the four groups in % body fat. (R:9.26 + 2.93,S:12.39 + 2.43,W:9.74 + 4.15,C:11.36 + 3.36%). Also the total abdominal fat volume and abdominal subcutaneous fat volume were not different among groups. However, the visceral fat volume in the R group was significantly lower than the C and S groups (mean + SD, R = 0.40 + 0.27; S = 0.95 + 0.46; W = 0.66 + 0.26; C = 0.85 + 0.33 L, P < 0.05). Fasting serum leptin, insulin, and testosterone did not differ significantly among groups (leptin, R: 1.64 + 0.62, S: 2.51 + 0.73, W: 2.38 + 1.76, C: 2.30 + 1.80 µg/L; insulin, R: 13.51+ 5.17, S: 17.15 + 4.42, W: 17.22 + 12.93, C: 15.45+ 6.13 ng/ml: testosterone, R: 7.05+ 1.63, S: 5.58 + 1.41, W: 6.06+ 1.13, C: 6.16+ 2.34 ng/ml). But leptin was significantly correlated with abdominal total adipose tissue volume and abdominal subcutaneous fat volume for all 4 groups. When the ratio of abdominal visceral fat volume (AVFV) to total abdominal fat volume (TAFV) was smaller (R:0.18, W:0.21), leptin and AVFV were significantly correlated (R = 0.89, W = 0.72, P < 0.05);when the ratio of AVFV to TAFV was larger (S:0.26, C:0.28), leptin and AVFV were not correlated. No significant relationship between leptin and insulin, leptin and testosterone was observed in R, S and W groups. Conclusions: Long-term regular exercise can help to maintain and decrease body fat. Long-term runners have the lowest visceral fat volume. Based on the relationship between leptin and abdominal fat volume distribution, adipose tissue volume is an important factor for correlation with leptin. Further research is needed in order to understand difference between long-term exercisers and sedentary individuals in concerning the ratio of AVFV to TAFV change and leptin.
一、 中文部份
王文獻譯。(1997)。人體生理學。台北市:合記圖書出版社。
詹光裕。(1993)。癌症之醫學影像診斷。中華癌醫會誌,9(1): 15-19。new window
謝伸裕、詹光裕。(1995)。臺灣地區華人身體組成的評量和體脂肪百分比預測
公式的發展研究。國科會專題研究報告,著作編號 : NSC84-2413-H003-
024。
謝伸裕、詹光裕。(1997)。臺灣地區華人體脂肪百分比公式的效度評估。國科
會專題研究報告,著作編號 : NSC86-2417-H003-009。
曹德弘。(1998)。腰圍和腰臀圍比與內臟脂肪體積的相關研究。未出版的碩士
論文,國立臺灣師範大學體育研究所,台北市,臺灣。
二、 英文部份
Abate, N., Burns, D., Peshock, R. M., Garg, A., & Grundy, S. M. (1994). Estimation
of adipose tissue mass by magnetic resonance imaging: validation against
dissection in human cadavers. Journal of Lipid Research, 35, 1490 - 1496.
Arslanian, S. & Suprasongsin, C. (1997). Testosterone treatment in adolescents with
delayed puberty: changes in body composition, protein, fat, and glucose
metabolism. Journal of Clinical Endocrinology and Metabolism, 82, 3213 —
3220.
Banerji, M. A., Faridi, N., Atluri, R., Chaiken, R. L., & Lebovitz, H. E. (1999). Body
composition, visceral fat, leptin, and insulin resistance in Asian Indian Men.
Journal of Clinical Endocrinology and Metabolism, 84, 137 — 144.
Banerji, M. A., Chaiken, R. L., Gordon, D., Kral, J. K., Lebovitz, H. E. (1995). Does
intra-abdominal adipose tissue in black men determine whether NIDDM is
insulin-resistant or insulin-sensitive? Diabetes, 44, 141 — 146.
Baumgartner, R. N., Waters, D. L., Morley, J. E., Patrick , P. Montoya, G.D. Garry , P.
J. (1999). Age-related changes in sex hormones affect the sex difference in
serum leptin independently of changes in body fat. Metabolism, 48(3):378-384
Behre, H. M., Simoni, M., & Mieschalg, E. (1997). Strong association between serum
levels of leptin and testosterone in men. Clinical Endocrinology, 47, 237-230.
Beld, A. W., Jong, F. H., Geobbee, D. E., Pols, H. A., & Lamberts, S. W. (2000).
Measures of bioavailable serum testosterone and estradiol and their relationships
with muscle strength, bone density, and body composition in elderly men.
Journal of Clinical Endocrinology and Metabolism, 85, 3276 — 3282.
Boden, G., Chen, X., Mozzoli, M., Ryan, I. (1996). Effects of fasting on serum leptin
in normal human subjects. Journal of Clinical Endocrinology and Metabolism,
81, 3419 — 3422.
Callaway, C. W., Chumlea, W. C., Bouchard, C., Himes, J. H., Lohman, T. G., Martin,
A. D., Mitchel, C. D., Mueller, W. H., Roche, A. F., & Seefeldt, V. D. (1988). In :
Lohman, T. G., Roche, A. F., & Martorell, R. (Eds). Anthropometric
Standardization Reference Manual Measurement (Abridged edition) (pp. 44 —
47). Champaign, Il : Human Kinetics Books.
Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995). Recombinant
mouse OB protein : evidence for a peripheral signal linking adiposity and central
neural networks. Science, 269, 547-549 .
Coleman, D. L. (1987). Obese and diabetes : two mutant genes causing diabetes-obese
syndromes in mice. Diabetologic, 14, 141 — 148.
Collins, S., Kuhn, C. M., Petro, A. E., Swick, A. G., Chrunyk, B. A., & Surwit, R. S.
(1996). Role of leptin in fat regulation. Nature, 380, 677.
Dagogo-Jack, S., Fanelli, C., Paramore, D., Brother, J., & Landt, M. (1996). Plasma
leptin and insulin relationship in obese and nonobese humans. Diabetes, 45,
695 — 698.
Despres, J-P., Prud'homme, D., Pouliot, M., Tremblay, A., Bouchard, C., Moorjani,
S., Nadeau, A., Lupien, P. J.& Theriault, G.(1989). Role of deep abdominal fat in
he association between regional adipose tissue distribution and glucose tolerance
in obese women. Diabetes, 38, 304-309.
Doucet, E., St-pierre, S., Almeras, N., Mauriege, P., Despres, J., Richard, D.,
Bouchard, C., & Tremblay, A. (2000). Fasting insulin levels influence plasma
leptin levels independently from the contribution of adiposity: evidence from
both a cross- sectional and an intervention study. Journal of Clinical
Endocrinology and Metabolism, 85, 4231 — 4237.
Dua, A., Hennes, M. I., Hoffmann, R. G., Maas, D. L., Krakower, G. R., Sonnenberg,
G. E., & Kissebah, A. H. Leptin : a significant indicator of total body fat but not
of visceral fat and insulin insensitivity in African-American women. Diabetes,
45, 1635-1637.
Fros, H., Matsuoka, H., Bosaeus, I., Roberg, S., Wikland, A. K., & Bjarnason, R.
(1999). Serum leptin levels correlate wit growth hormone secretion and body fat
in children. Journal of Clinical Endocrinology and Metabolism, 84, 3586 — 3590.
Ganong, W. F. (1999). Review of medical physiology. Connecticut: Appleton &
Lange.
Geffory, S., Vos, P. D., Staels, B., Duban, B., Auwerx J., & Martinville, B. D. (1995).
Localization of the human OB gene (OBS) to chromosome 7q32 by fluorescence
in situ hybridization. Genomics, 28, 602 — 603.
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D.,
Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995). Weight-reducing effects
of the plasma protein encoded by the obese gene. Science, 269, 543-546.
Hamilton, B., Paglia, D., Kwan, A. Y. M., & Deitel, M. (1995). Increased obese
mRNA expression in omental fat cells from massively obese humans. Nature
Medicine, 1, 953 — 956.new window
Harmelen, V. V., Reynisdottir, S., Eriksson, P., Thorne, A., Hoffstedt, J., Lonnquist F.,
& Arner, P. (1998). Leptin secretion from subcutaneous and visceral adipose
tissue in Women. Diabetes, 47, 913-917.
Hervey, G. R. (1958). The effects of lesions in parabiotic rats. Journal of Physiology,
145, 336 — 352.
Hickey, M. S., Considine, R. V., Israel, R. G., Mahar, T. L., Mccamon, M. R., Tyndall,
G. L., Houmard, J. A., & Caro, G. L. (1996). Leptin is related to body content in
male distance runners. American Journal of Physiolgy, 271, E938 — E940.
Isidori, A. M., Strollo, F., More, M., Caprio, M., Aversa, A., Moretti, C., Frajese, G.,
Riondino, G., & Fabbri A. (2000). Leptin and aging: correlation with endocrine
changes in male and female healthy adult population of different body weights.
Journal of Clinical Endocrinology and Metabolism, 85, 1954 — 1962.
Kennedy, G. C. (1953). The role of depot fat in the hypothalamic control of food
intake in the rat. Proceedings of the Royal Society of Medicine, 140, 578 — 592.
Kissebah, A. H., Vydelingum, N., Murray, R., Evans, D. J., Hartz, A. J., Kalkhoff, R.
K., Adams, P. W. (1982). Relation of body fat distribution to metabolic
complications of obesity. Metabolism, 54, 254 — 260.
Klein, S., Coppck, S. W., Mohamed-Ali, V., Landt, M. (1996). Adipose tissue leptin
production and plasma leptin kinetics in humans. Diabetes, 45, 984 — 987.
Kristensen, P., Judge, M. E., Thim, L., Ribel, U., Christjansen, K. N., Wulff, B. S.,
Clausen, J. T., Jnsen, P. B., Madsen, O. D., Vrang, N., Larsen, P. J., & Hastrup,
S. (1998). Hypothalamic CART is a new anorectic peptide regulated by leptin.
Nature, 393, 72 — 76.
Kvist, H., Chowdury, B., Gangard, U., Tylen, U., Sjostrom, L. (1988). Adipose tissue
volume determination in males by computed tomography and 40K. International
Journal of Obesity, 12, 249 — 266.
Leal-Cerro, A., Garcia-Luna, P. P., Astorga, R., Parejo, J., Peino, R., Dieguez, C., &
Casanueva, F. F. (1998). Serum leptin levels in male marathon athletes before
and after the marathon run. Journal of Clinical Endocrinology and Metabolism,
83, 2376 — 2376.
Lee, G. H., Proenca, R., Montez, J. M., (1996). Abnormal splicing of the leptin
receptor in diabetic mice. Nature, 379, 632 — 635.
Lewin, B. (2000). Genes VII. New York : Oxford University Press.
Lemieux, B., Prud’homme, D., Bouchard, C., Tremblay, A., & Despres, Jean-Pierre.
(1993). Sex difference in the relation of visceral adipose tissue accumulation to
total body fatness. American Journal of Clinical Nutrition, 58, 463 — 467.
Lönnqvist, F., Arner, P., Nordfors, L., & Schalling, M. (1995). Overexpression of the
obese (ob) in adipose tissue of human obese subjects. Nature Medicine, 1, 950 —new window
953.
Lönnqvist, F., Nordfors, L., Jansson, M., Thorne, A., Schalling, M., & arner, P.
(1997). Leptin secretion from adipose tissue in women : relationship to plasma
and gene expression. Journal of Clinical Investigation, 99, 2398 — 2404.
Luukkaa V., Pesonen, U., Huhtaniemi, I., Lehtonen, A. Tilvis, R., Tuomilehto, J.,
Koulu, M. Huupponen, R. (1998). Inverse correlation between serum
testosterone and leptin in men. Journal of Clinical Endocrinology and
Metabolism, 83:3243-3246.
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H.,
Kim, S., Lallone, R., Ranganathan, S., Kern, P. A., & Friedman, J. M. (1995).
Leptin levels in human and rodent : measurement of plasma leptin and ob RNA
in obese and weight-reduced subjects. Nature Medicine, 1, 1155-1161.new window
Masuzaki, H., Ogawa, Y., Isse, N., Satoh, N., Okazaki, T., Shigemoto, M., Mori, K.,
Tamura, N., Hosoda, K., Yoshimasa, Y., Jingami, H., Kawada, T., & Nakao, K.
(1995). Adipocyte — specific expression and regional difference in the adipose
tissue. Diabetes, 44, 855-858.
Matejek, N., Weimann, E., Witzel, C., Molenkamp, G., Schwidergall, S., & Bohles,
H. (1999). Hypoleptinaemia in patients with anorexia nervosa and elite gymnasts
with anorexia athletics. International Journal of Sports Medicine, 20, 451 — 456.
Monteleone, P., Bortolotti, F., Fabrazzo, M., Rocca, A. L., Fushino, A., & Maj, M.
(2000). Plasma leptin response to acute fasting and refeeding in untreated women
with bulimia nervosa. Journal of Clinical Endocrinology and Metabolism, 85,
2499 — 2503.
Morimoto, S., Fernandez-Mejia, C., Romero-Navarro, G., Morales-Peza, N., Diaz-
Sanchez, V. (2001). Testosterone effect on insulin content, messenger ribonucleic
acid level, promoter activity, and secretion in the rat. Endocrinology, 142, 1442 —
1447.
Murry, R. K., Granner, D. K., Mayes, P. A., & Rodwell, V. W. (2000). Harper’s
Biochemistry (25th ed). Connecticut: Appleton & Lange.
Neuhauser-Berthold M., Herbert, B. M., Luhrmann, P. M., Sultemeier, A., Blum, J. F.,
& Hebebrand, J. (2000). Resting metabolic rate, body composition, and serum
leptin concentration in a free-living elderly population. European Journal of
Endocrinology, 142, 486 — 492.
Noland, R. C., Baker, J. T., Boudreau, S. R., Kobe, R. W., Tanner, C. J., Hickner, R.
C., Mccammon, M. R., & Houmard, J. A. (2001). Effect of intense training on
plasma leptin in male and female swimmers. Medicine & Science in Sports &
Exercise, 33 (2), 227 — 231.
Ohlson, L-o., Larsson, B., Svardsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L.,
Bjorntorp, P., & Tibblin, G. (1985). The influence of body fat distribution on the
incidence of diabetes mellitus : 13.5 years of follow-up of the participants in the
study of men born in 1913. Diabetes, 34, 1055-1058.
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T.,
&Collins, F. (1995). Effects of the obese gene product on body weight
regulation in ob/ob mice. Science, 269, 540-543.
Pouliot, M., Despres, J-P., Lemieux, S., Moorjani, S., Bouchard, C.,& Tremblay,
A.(1994). Waist circumference and abdominal sagittal diameter: Best simple
anthropometric indexes of abdominal visceral adipose tissue accumulation and
related cardiovascular risk in men and women. The American Journal of
Cardiology, 73,460-468.
Ronnemaa, T., Karonen, S., Rissanen, A., & Koskenvuo, M., Koivisto, V. A. (1996).
Relation between plasma leptin levels and measures of body fat in identical twins
discordant for obesity. Annuals of Internal Medicine, 126 (1), 26 — 31.new window
Rosenbaum, M., Nicolson, M., Hirsch, J., Heymsfield, S. B., Gallagher, D., Chu, F.,
Leibel, R. L. (1996). Effects of gender, body composition, and menopause on
plasma concentrations of leptin. Journal of Clinical Endocrinology and
Metabolism, 81, 3424 — 3427.
Rosenbaum, M., Nicolson, M., Hirsch, J., Murphy, E., Chu, F., & Leibel, R. L. (1997).
Effects of weight change on plasma leptin concentration and energy expenditure.
Journal of Clinical Endocrinology and Metabolism, 82, 3647 — 3654.
Ross, R., Shaw, K., Rissanen, J., Martel, Y., Guise, J., & Avruch, L. (1994) Sex
difference in lean and adipose tissue distribution by magnetic resonance imaging:
anthropometric relationships. American Journal of Clinical Nutrition, 59, 1277 —
1285.
Ross, R., Leger, L., Guardo, R., Guise, J. D.,& Morris, D.(1992). Quantification of
adipose tissue by MRI : Relationship with anthropometric variables. Journal of
Applied Physiology,72(2),787-795.
Saladin, R., Vos, P. D., Guerre-Millo,M., Leturque, A., Girard, J., Staels, B., &
Auwerx, J. (1995). Transient increase in obese gene expression after food intake
or insulin. Nature, 377, 527 — 529.
Segal, K. R., Landt, M., & Klein, S. (1996). Relationship between insulin sensitivity
and plasma leptin concentration in lean and obese men. Diabetes, 45, 988 — 991.
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G.,
Craft, L., Hale, J., Hoffman, J., Hsiung, H. M., Kriauciunas, A., MacKeller, W.,
Jr, R. P. R., Schoner, B., Zhang, X., & Heiman, M. (1995). The role of
neuropeptide Y in the antiobesity action of the obese gene product. Nature, 377,
530 — 532.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R.,
Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S.,
Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C.
A., & Tepper, R. I. (1995). Identification and expression cloning of leptin
receptor, OB-R. Cell, 83, 1263 — 1267.
Tarui, S., Tokunaga, K., Fujioka, S., & Matsuzawa, Y. (1991). Visceral fat obesity:
anthropological and pathophysiological aspects. International Journal of Obesity,
15 Suppl 2, 1-8.
Torjman, M. C., Zafeiridis, A., Paolone, A. M. Wilkerson, C., & Considine, R. V.
(1999). Serum leptin during recovery following maximal incremental and
prolonged exercise. International Journal of Sport Medicine, 20, 444-450.
Tsao, T. H., Hsieh, S. S., Huang, T. H., & Chan, K. Y. (2000). Assessment of gender
Differences in visceral fat from waist girth and hip circumference. Medicine &
Science in Sport & Exercise, 32, s87.
Tuominen, J. A., Ebeling, P., Heiman, M. L., Stephens, T., & Koivisto, T. (1997).
Leptin and thermogenesis in humans. Acta Physiological Scandinavian , 160,
83 — 87.
Weinser, R. L., Norris, D. J., Birch, R., Bernstein, R. S., Wang, J., Yang, M. — U.,
Pierson, R. N., & Van Itallie, T. B.(1985). The relative contribution of body fat
and fat patter to blood pressure level. Hypertension, 7, 578 — 585.
Zhang, Y., Proenca, R., Maffei, M., Barone, M. Leopold, L. & Friedman, J. M.
(1994). Positional cloning of the mouse obese gene and its human homologue.
Nature, 372, 425-432.
 
 
 
 
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