精胺酸補充劑對運動後葡萄糖、游離脂肪酸及抗疲勞的影響_

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題名：	精胺酸補充劑對運動後葡萄糖、游離脂肪酸及抗疲勞的影響
作者：	蔡佈曦
作者(外文)：	Pu-Hsi Tsai
校院名稱：	國立體育學院
系所名稱：	體育研究所
指導教授：	許美智
學位類別：	博士
出版日期：	2007
主題關鍵詞：	代謝反應；抗疲勞作用；精胺酸；arginine；anti-fatigue effect；metabolic responses
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:36

本研究分兩部分，第一個研究在探討補充精胺酸對於人體抗疲勞的影響。本實驗採用隨機、雙盲、交叉設計，研究對象為12位健康男學生，每天補充安慰劑(PL組)或精胺酸(AR組)0.2g/kg/wt，為期28天，經過14天的停用期，再補充精胺酸或安慰劑。在補充期之後進行單次跑步機力竭運動，於運動前、運動中第15分鐘、運動後第0、20、60、120分鐘進行靜脈採血。並以氫磁振光譜(1H-MRS)測量精胺酸補充前後比目魚肌及脛前肌中肌酸儲存量的變化。
研究結果顯示補充AR組運動力竭時間顯著高於PL組，而力竭點的血乳酸濃度AR組顯著高於PL組，運動恢復期AR組的血糖濃度於運動後60及120分鐘顯著高於PL組。血氨、肌酸激酶、游離脂肪酸、氧脈、比目魚肌及脛前肌中的肌酸儲存量則兩組之間沒有顯著差異。以上結果顯示，補充精胺酸有助於高強度力竭運動的運動表現及生理上恢復的效果，表示精胺酸在力竭運動後具抗疲勞的效益。
第二個研究旨在探討補充精胺酸對於運動員在耐力運動恢復期代謝反應的影響。本研究對象為12位健康柔道選手，以強度75%VO2max之跑步機耐力運動60分鐘後隨機分兩組，補充精胺酸或安慰劑0.1g/kg/wt，經過兩週以後，再交換補充精胺酸或安慰劑。於運動前、運動後第0、15、30、45、60、90、120分鐘進行靜脈採血。測量血液中血糖、胰島素、游離脂肪酸、甘油、血乳酸、血氨、肌酸激酶、細胞介質素-6、及一氧化氮的濃度。
研究結果顯示：運動後恢復期間之甘油、血乳酸、血氨、肌酸激酶活性、細胞介質素-6、及一氧化氮兩組間並未達顯著差異。而AR組之血糖濃度於運動後15分鐘顯著高於PL組，胰島素濃度於運動後30分鐘AR組顯著高於PL組、游離脂肪酸濃度AR組於運動後30及40分鐘顯著低於PL組。總結以上結果，本研究發現，補充精胺酸有助於運動後恢復期增加血糖及胰島素濃度，並增加肌肉對游離脂肪酸的利用。

以文找文

This research involves two studies, the first study was to investigate the effects of arginine supplementation on antifatigue. In this randomized, double blind, crossover study, twelve healthy subjects took either a placebo or an arginine supplement 0.2g/kg-wt for a total of 28 days, followed by a 14 days washout period; and then resumed the arginine supplement or placebo. After supplement period, they performed a single bout of exercise to exhaustion. Blood samples were collected before exercise, at exercise 15min, at exhaustion and 20, 60, and 120 minutes during the recovery period. In vivo proton magnetic resonance spectroscopy (1H-MRS) was used to measure creatine levels in Soleus and Tibialis Anterior muscle before and after arginine supplementation.
It was observed that exercise time to exhaustion was significantly higher in the arginine group compared to that in the placebo group. The lactate concentration at exhaustion was higher in the arginine group compared to that in the placebo group. Additionally, the glucose levels at 60, and 120 minutes of the recovery period were significantly higher in the arginine group compared to those in the placebo group. There were no differences in plasma ammonia, creatine kinase, free fatty acid, O2 pulse, or creatine levels in Soleus and Tibialis Anterior muscle between treatments. The results indicated that arginine supplementation before an exhaustive exercise could enhance exercise performance and physiological recovery in humans. It demonstrated that ingestion of arginine essence offers anti-fatigue benefits after exhaustive exercise.
The second study was to investigate the effects of arginine supplementation on acute metabolic responses during recovery after a single bout of endurance exercise in trained athletes. Twelve healthy male judo athletes were randomly divided into two groups and performed a single bout of exercise at a speed estimated to correspond to 75% VO2max for 60 minutes, and then took either a placebo or arginine at 0.1g/kg-wt. Blood samples of each athlete were collected before exercise, and 0, 15, 30, 45, 60, 90, 120 minutes after exercise, respectively. The experiment was repeated two weeks later, but treatments were exchanged for two groups. The concentrations of glucose, insulin, free fatty acid (FFA), glycerol, lactate, ammonia, creatine kinase, IL-6 and NOx (NO2- + NO3-) in blood were examined. No differences in the levels of glycerol, lactate, ammonia, creatine kinase, IL-6 or NOx between the two groups were observed at any of the time points. However, the concentration of glucose was significantly higher in the arginine group, compared to that in the placebo group at the 15 minutes recovery period. The insulin concentration was higher in the arginine group compared to that in the placebo group at the 30 minutes recovery period. Furthermore, the free fatty acid levels at 30, and 45 minutes recovery periods were significantly lower in the arginine group compared to those in the placebo group. The results indicate that arginine supplementation during exercise recovery period could increase glucose and insulin concentrations, and increase FFA availability in muscle.

以文找文

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