The eleventh century is the era of knowledge economy, knowledge will become the organization to enhance the quality and competitive advantage of the key factors. Therefore, the effective use of knowledge management strategy, will be an important issue in the future business, combined with quality control circle, so that enterprises effectively collect, organize, transform, create, preserve, accumulate, disseminate and use knowledge, make knowledge important Resources, and thus enhance the competitiveness. In recent years, technology has been changing with each passing day. In the 21st century, the printing industry, which belongs to the traditional technology, can no longer compete with other peers in the same way. In the continuous development of production equipment, the printing industry needs to constantly replace the new equipment in order to maintain the competitive advantage, Not to mention the huge amount of money needed to replace the equipment, and as the network progresses more and more, it reduces the reliance on printing, and many of the information can be viewed more quickly and easily from the web. But because there are still many activities are inseparable from the printing industry, such as a variety of large and small advertising and leaflets, books, labels and even clothes on the pattern are inseparable from the printing industry, which shows the printing industry also occupies a market Very important position. Coupled with the current young people have a bad impression on the traditional industries, making the printing industry to recruit new blood of the difficulties, but even to recruit new blood is often new people are also unable to bear the temper often leave, but also because of the above reasons New employees can not grasp the rhythm, making the annual loss of business income, so through the establishment of its knowledge management system to help enterprises to quickly find their employees in the work of positioning and value. This paper explores the importance and purpose of knowledge management and quality control circle by the literature, establishes the knowledge management system of the case company and improves the ability of the company to improve the business of the company, and then collects the data before the questionnaire, Software to carry out statistical analysis to verify, will encounter problems and improve the direction of the proposal, as the printing industry in Taiwan to implement quality management and knowledge management reference.