本研究旨在探討高強度衰竭運動之後的老鼠肺臟、心臟、肝臟及腎臟脂質過氧化物的變化情形。二十隻雄性的白老鼠為實驗動物，隨機分配到衰竭運動組與控制組(N=10)。衰竭運動組的老鼠在老鼠跑步機上以陡度10%，每分鐘15公尺的速度先跑15分鐘勢身，然後逐漸增加速度與時間，分別為25公尺/分跑15分鐘、30公尺/分跑30分鐘、35公尺/分跑60分鐘、40公尺/分跑30分鐘、45公尺/分跑30分鐘，真到跑至衰竭為止，老鼠的平均衰竭時間為104.28±33.64分鐘，平均衰竭時的運動強度為每分鐘35公尺的速度、衰竭運動後取出老鼠的肺臟、心臟、肝臟及腎臟。控制組亦在同一時間取出上述器官。脂質過氧化物丙二醇的含量是以Chiu&Claster的方法來測量。結果顯示，衰竭運動組老鼠肺臟、心臟、肝臟的丙二醇含量顯著高於控制組。至於腎臟的丙二醇含量，則衰竭運動組與控制組之間沒有達到顯著差異。因此，本研究認為過度的激烈運動使老鼠肺臟、心臟、肝臟的氧化壓力增加，進而引起氧化傷害。然而，腎臟可能因為產生的氧化壓力不大或抗氧化物的增加，所以在衰竭運動後並沒有明顯的氧化傷害。

The purpose of this study was to investigate the effect of exhaustive exercise on lipid peroxidation in rat lung, heart, liver and kidney. Twenty male Sprague-Dawley rats were randomly divided into the following two gropups:1)exhaustive exercise, and 2) control group(n=10). The exhaustive exercise started at 10% grade, 15m/min for 15 min followed by gradual increases of treadmill speed and time as 25 m/min for 15 min, 30m/min for 30 min, 35m/min for 60 min, 40m/min for 30min, 45m/min for 30 min until exhaustion. Average run time to exhaustion was 104.28±33.64min, and average exercise strength to exhaustion was at speed of 35m/min. The lung, heart, liver and kidney of the rat were taken after exhaustive exercise. At the same time control group was also done, the value of molondialdehyde (MDA) was measured by the method of Chiu & Claster. The results showed that MDA in lung, heart, and liver of exhaustive exercise groups was significantly higher than control group. However, the value of MDA in kidney was no significant difference between two groups. It is concluded that exhaustive exercise results to oxidative stress leading to oxidative damage in rat lung, heart and liver, while the oxidative damage on kidney does not occur.