Main purpose was being investigated in the study: To explore necessary counseling skills for nursing practitioners to deal with patients' bio-psycho-social problem. Focus group interviews were conducted to collect opinions from different perspectives, including patients, nurses, nursing assistants, college nursing students, and nursing college instructors. The result revealed that patients and their family members did expect nurses to have the ability to help them cope with disease related questions. Five most necessary counseling skills that a nurse was expected to have were identified as following: (1) Gaining patients' trust and cooperation by professional skills and attitudes. (2)Being able to educate patients regarding to health issues. (3) Paying attention and being sensitive to patients' bio-psycho-social problems. (4) Assisting patients' to establish their social support system and hopes. (5) Being able to control and adjust emotional status of both nurses and patients. Based on the results of this study, implications and suggestions were proposed for chronic illness and nursing education. Further possible research directions were discussed at the end.