目的：長程聽覺誘發波的產生除了牽涉對聲音的刺激反應之外，還包括認知活動。N100、P200、N200、P300是最常被用來分析的四個波型組合。本研究的目的在於探討未接受過藥物治療的精神分裂症個案長程聽覺誘發波變化。方法：本研究以未接受過治療之精神分裂症個案37人，曾經接受過治療至少停藥四週之精神分裂症個案29人，以簡短精神症狀評量表來評估其精神症狀。另取同年齡層的正常人55人對照組，三組個案同時接受聽覺誘發波的檢測。結果：兩組病患的組間比較其聽覺誘發波的變化結果無差異，而與正常對照組比較皆為N100及P300振幅降低、N200潛時延長。而精神症狀分組中的負性症狀與N200潛時、P300振幅有顯著性相關；正性症狀與聽覺誘發波的組成沒有相關性。結論：未接受過藥物治療的精神分裂症患者的N100及P300振幅降低、N200潛時延長。

　　　　　Objective: The generation of long-latency auditory event-related potentials involves the response to external acoustic stimuli, and also reflects cognitive activities. The four electrophysiological components most frequently studied are N100, P200, N200, P300. The various components of auditory event-related potentials were studied in drug-naive schizophrenic patients to examine the electrophysiological changes. Methods: Enrolled subjects were categorized into three groups, designated as drug-naive schizophrenia, drug-free schizophrenia and normal control. Thirty-seven drug-naive patients and 29 who had been drug-free for at least four weeks were selected for the first two categories. Psychiatric symptoms were assessed and scored according to BPRS. The control group consisted of 55 normal age-matched individuals. Auditory event-related potentials were investigated for all three groups of patients based on the oddball paradigm. Results: Decreased amplitudes for N100 and P300 components were observed for the two psychiatric-patient groups, while N200 latency was prolonged. Negative symptoms were correlated with prolonged N200 latency and decreased P300 amplitude, with no significant correlation demonstrated for positive symptoms and auditory event-related potentials. Conclusion: No statistically significant difference was demonstrated for long-latency response parameters comparing drug-naive and drug-free schizophrenia patient groups. For our schizophrenic patients, the decreased amplitude demonstrated for both the N100 and P300 components, and the prolonged N200 latency are comparable with most other studies.