精神分裂症之生理病理學__臺灣人文及社會科學引文索引資料庫

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題名：	精神分裂症之生理病理學
書刊名：	臺灣精神醫學
作者：	楊延光／葉宗烈／李怡慧
作者(外文)：	Yang, Yen Kuang／Yeh, Tzung Lieh／Lee, I Hui
出版日期：	2001
卷期：	15:4
頁次：	頁261-276
主題關鍵詞：	精神分裂症；生理病理機轉；多巴胺接受體；神經迴路；Schizophrenia；Pathophysiology；Dopamine receptor；Neural circuit
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(1) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:1 共同引用:8 點閱:60

　　　　　精神分裂症是相當盛行的嚴重精神疾病，其生理病理致病機轉由於基因或（及）其他環境誘因導致胎兒於胚胎中期起發育受損，因故產生解剖性及神經化學的病變；再加上神經細胞可塑性及環境因素複雜的互動影響，導致認知功能缺損、負性症狀、正性症狀於是次第產生。由於皮質間聯結病變與症狀及認知功能缺損關係密切，日後研究除了致病基因之探索外，針對認知功能發展過程中相關神經迴路及結構變化之研究，也將有助於致病因之了解。

以文找文

　　　　　Schizophrenia is one of the prevalent and severe psychiatric disorders. Its pathophysiology involves complex interaction among genes and many biopsychosocial factors. Anatomical and neurochemical pathology had been demonstrated in patient with schizophrenia. Clinically, cognitive deficient, negative symptoms and positive symptoms were occurred gradually in patients' at aldolesent or early adulthood. Because, cognitive defici and psychopathology were highly associated with the dysfunction of intercortical connection, it is necessary, in additional to genetic study, to explore the relationship among cognitive development, neural circuit and anatomical changes in human being in the future for research of etiology of schizophrenia.

以文找文

期刊論文
1.	Lauriello, J.、Bustillo, J.、Keith, S. J.(1999)。A critical review of research on psychosocial treatment of schizophrenia。Biological Psychiatry，46(10)，1409-1417。
2.	Nayani, T.、David, A. S.(1996)。The auditory hallucination: A phenomenological survey。Psychological Medicine，26(1)，177-189。
3.	Hwu, H. G.、Yeh, E. K.、Chang, L. Y.(1989)。Prevalence of psychiatric disorders in Taiwan defined by the Chinese Diagnostic Interview Schedule。Acta Psychiatrica Scandinavica，79(2)，136-147。
4.	葉玲玲、李玉春、楊銘欽、劉絮愷、胡海國(19970900)。嚴重精神病患經濟成本分析。中華心理衛生學刊，10(3)，1-15。延伸查詢
5.	Lin, T. Y.(1953)。A study of the incidence of mental disorder in Chinese and other cultures。Psychiatry，16，13-36。
6.	Murray, R. M.、Lewis, S. W.(1987)。Is schizophrenia a neuro-developmental disorder?。British Medical Journal (Clinical Research Ed.)，295，681-682。
7.	Van Dyck, C. H.、Abi-Dargham, A.、Laruelle, M.、Gil, R.、D'Souza, C. D.、Erdos, J.、Baldwin, R. M.(1996)。Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects。Proceedings of the National Academy of Sciences of the United States of America，93，9235-9240。
8.	Hantraye, P.、Paillere-Martinot, M. L.、Dao-Castellana, M. H.(1997)。Presynaptic dopaminergic function in the striatum of schizophrenic patients。Schizophrenia Research，23，167-174。
9.	胡海國、陳珍信、黃宗正、Liu, C.-M.、Cheng, J.-J.、Lin, S.-K.、Chen, W.-J.(2002)。Symptom Patterns and Subgrouping of Schizophrenic Patients: Significance of Negative Symptoms Assessed on Admission。Schizophrenia Research，56，105-119。
10.	Schultz, W.(1998)。Predictive reward signal of dopamine neurons。The Journal of Neurophysiology，80(3)，1-27。
11.	Reyes, A.、Galarraga, E.、Surmeier, D. J.、Bargas, J.、Hernandez-Lopez, S.(1997)。D1 receptor activation enhances evoked discharge in neostriatal medium spiny neurons by modulating an L-type Ca2+ conductance。The Journal of Neuroscience，17，3334-3342。
12.	Garris, P. A.、Wightman, R. M.(1994)。Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study。The Journal of Neuroscience，14，442-450。
13.	Grace, A. A.、West, A. R.、Moore, H.(1999)。The regulation of forebrain dopamine transmission: relevance to the pathophysiology and psychopathology of schizophrenia。Biological Psychiatry，46，40-55。
14.	Grace, A. A.(1993)。Cortical regulation of subcortical dopamine systems and its possible relevance to schizophrenia。Journal of Neural Transmission - General Section，91，111-134。
15.	Grace, A. A.(1991)。Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia。Neuroscience，41，1-24。
16.	Carlsson, A.(1988)。The current status of the dopamine hypothesis of schizophrenia。Neuropsychopharmacology，1，179-186。
17.	Buchanan, R.、Thaker, G. K.、Tamminga, C. A.(1992)。Limbic System abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome。Archives of General Psychiatry，49，522-530。
18.	Pearlson, G. D.(1981)。Psychiatric and medical syndromes associated with phencyclidine (PCP) abuse。Johns Hopkins Medical Journal，148，25-33。
19.	Porter, R. H.、Greenamyre, J. T.(1994)。Anatomy and physiology of glutamate in the CNS。Neurology，44，7-13。
20.	Tamminga, C. A.(1998)。Schizophrenia and glutamatergic transmission。Critical Review of Neurobiology，12，21-36。
21.	Whetsell, W. O.、Shapira, N. A.(1993)。Neuroexcitation, excitotoxicity and human neurological disease。Laboratory Investigation，68，372-387。
22.	Carlsson, M. L.、Waters, N.、Carlsson, A.(1999)。Neurotransmitter interactions in schizophrenia - Therapeutic implications。Biological Psychiatry，46，1388-1395。
23.	Saunders, R.、Su, T. P.、Breier, A.(1997)。Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method。Proceedings of the National Academy of Sciences of the United States of America，94，2569-2574。
24.	Seidman, L. J.、Stone, W. S.、莊明哲(1999)。Treatment of nonpsychotic relatives of patients with schizophrenia: Four case studies。Biological Psychiatry，45，1412-1418。
25.	Weinberger, D. R.、Gallhofer, B.(1997)。Cognitive function in schizophrenia。International Clinical Psychopharmacology，12，29-36。
26.	Andreasen, N. C.(1999)。A unitary model of schizophrenia: Bleuler's 'fragmented phrene' as schizencephaly。Archives of General Psychiatry，56，781-787。
27.	McDermott, B.、Croissant, D.、Kingsbury, S. J.、Ramberg, J. E.、Garver, D.、Knoll, J. L.(1998)。Heterogeneity of the psychoses: Is there a neurodegenerative psychosis?。Schizophrenia Bulletin，24，365-379。
28.	Hulshoff, Pol H. E.、Van Oel, C. J.、Baare, W. F.(2001)。Volumes of brain structures in twins discordant for schizophrenia。Archives of General Psychiatry，58，33-40。
29.	Amador, X. F.、Yale, S. A.、Gorman, J. M.、Ratakonda, S.(1998)。Characterization of Psychotic Conditions: Use of the Domains of Psychopathology Model。Archives of General Psychiatry，55，75-81。
30.	Peralta, V.、Cuesta, M. J.(1999)。Diagnostic significance of Schneider's first-rank symptoms in schizophrenia: Comparative study between schizophrenic and non-schizophrenic psychotic disorders。The British Journal of Psychiatry，174，243-248。
31.	Robins, E.、Guze, S. B.(1970)。Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia。The American Journal of Psychiatry，126，983-987。
32.	Faraone, S. V.、Stone, W. S.、Tsuang, Ming T.(2000)。Toward reformulating the diagnosis of schizophrenia。The American Journal of Psychiatry，157，1041-1050。
33.	Gunderson, J. G.、Mosher, L. R.(1975)。The cost of schizophrenia。The American Journal of Psychiatry，132，901-906。
34.	Andrew, G.(1985)。The economic cost of schizophrenia。Archives of General Psychiatry，42，537-543。
35.	Weinberger, D. R.(1987)。Implications of normal brain development for the pathogenesis of schizophrenia。Archives of General Psychiatry，44(7)，660-669。
36.	Halldin, C.、Chou, Y. H.、Nyborg, S.(0)。Saturation of striated D2 dopamine receptor by clozpine。Int J Neuropsychophamacology。
37.	Gur, R. E.、Mozley, P. D.、Resnick, S. M.(1991)。Magnetic resonance imaging in schizophrenia I: Volummetric analysis of brain and cerebrospinal fluid。Archives of General Psychiatry，48，407-412。
38.	Byne, W.、Buchsbaum, M. S.、Kemether, E.(2001)。Magnetic Resonance Imaging of the Thalamic Mediodorsal Nucleus and Pulvinar in Schizophrenia and Schizotypal Personality Disorder。Archives of General Psychiatry，58，133-140。
39.	Andreasen, N. C.、O'Leary, D. S.、Flaum, M.(1997)。Hypofrontality in schizophrenia: distributed dysfunctional circuits in neuroleptic-naive patients。Lancet，349，1730-1734。
40.	Waddington, J. L.、Lane, A.、Scully, P. J.、Larkin, C.、O'Callaghan, E.(1998)。Neurodevelopmental and neuroprogressive processes in schizophrenia: Antithetical or complementary, over a lifetime trajectory of disease?。The Psychiatric Clinics of North America，21，123-149。
41.	Walker, E. F.(1994)。Developmentally moderated expressions of the neuropathology underlying schizophrenia。Schizophrenia Bulletin，20，453-480。
42.	Torrey, E. F.、Miller, J.、Rawlings, R.、Yolken, R. H.(1997)。Seasonality of births in schizophrenia and bipolar disorder: A review of the literature。Schizophrenia Research，28，1-38。
43.	Verdoux, H.、Takei, N.、Cassou De Saint-Mathurin, R.、Murray, R. M.、Bourgeois, M. L.(1997)。Seasonality of birth in schizophrenia: the effect of regional population density。Schizophrenia Research，23，175-180。
44.	Brown, A. S.、Susser, E. S.、Cohen, P.、Greenwald, S.(1998)。Schizophrenia following mental rubella exposure: Schizophrenia following specificity。Schizophrenia Research，29，17-18。
45.	Fatemi, S. H.、Sidwell, R.、Akhter, P.(1998)。Human influenza viral infection in utero increases nNOS expression in hippocampi of neonatal mice。Synapse，29，84-88。
46.	Susser, E.、Neugebauer, R.、Hoek, H. W.(1996)。Schizophrenia after prenatal famine. Further evidence。Archives of General Psychiatry，53，25-31。
47.	Van Os, J.、Selten, J. P.(1998)。Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of the Netherlands。The British Journal of Psychiatry，172，324-326。
48.	Waddington, J. L.、Buckley, P. F.、Scully, P. J.、Lane, A.、O'Callaghan, E.、Larkin, C.(1998)。Course of psychopathology, cognition and neurobiological abnormality in schizophrenia: developmental origins and amelioration by antipsychotics?。Journal of Psychiatric Research，32，179-189。
49.	陳為堅、Yeh, L. L.、Chang, C. J.、Lin, L. C.、Rin, H.、胡海國(1996)。Month of birth and schizophrenia in Taiwan: Effect of gender, family history and age at onset。Schizophrenia Research，20，133-143。
50.	陳嘉祥、Shih, Hsuan-Hui、王昇、戴政、武光東(1998)。Chromosomal fragile site expression in lymphocytes from patients with schizophrenia。Human Genetics，103，702-706。
51.	Waddington, J. L.、Lane, A.、Larkin, C.、O'Callaghan, E.(1999)。The neurodevelopmental basis of schizophrenia: Clinical clues from cerebro-craniofacial dysmorphogenesis, and the roots of a lifetime trajectory of disease。Biological Psychiatry，46，31-39。
52.	Lubinsky, M. S.(1987)。Midline Developmental "weakness" as a Consequence of Determinative Field Properties。American Journal of Medical Genetics，28(Suppl. 3)，23-28。
53.	Hyde, T. M.、Ziegler, J. C.、Weinberger, D. R.(1992)。Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis。Archives of Neurology，49，401-406。
54.	Weinberger, D. R.、Lipska, B. K.(1995)。Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground。Schizophrenia Research，16，87-110。
55.	Davison, K.、Bagley, C. R.(1969)。Schizophrenia-like psychosis associated with organic disorder of the control nervous system。The British Journal of Psychiatry，113，18-69。
56.	Jakob, H.、Beckman, H.(1986)。Prenatal developmental disturbances in the limbic allocortex in schizophrenia。Journal of Neural Transmission，65，303-326。
57.	楊延光、陳純誠、李怡慧(2003)。The association between regional cerebral blood flow and eye-tracking performance and the Wisconsin Card Sorting Test in schizophrenics: a single photon emission computed tomography study。Psychiatry Research，123(1)，37-48。
58.	劉絮愷、胡海國、陳為堅(1997)。Clinical symptom dimensions and deficits on the Continuous Performance Test in schizophrenia。Schizophrenia Research，25，211-219。
59.	陳為堅、劉絮愷、張景瑞、Lien, Ying-Ju、Chang, Yu-Hui、胡海國(1998)。Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients。The American Journal of Psychiatry，155，1214-1220。
60.	Lipska, B. K.、Weinberger, D. R.(1993)。Delayed behavioral disturbances associated with neonatal excitotoxic hippocampal damage in the rat: Effect of castration and neuroleptics。Soc Neurosci Abstracts，19。
61.	Lipska, B. K.、Weinberger, D. R.(1993)。Delayed effects of neonatal hippocampal damage on haloperidol-induced catalepsy and apomorphine-induced stereotypic behaviors in the rat。Brain Research, Developmental Brain Research，75，213-222。
62.	DeLisi, L. E.(1997)。The genetics of schizophrenia: Past, present, and future concepts。Schizophrenia Research，28，163-175。
63.	McGuffin, P.、Farmer, A. E.、Gottesman, I. I.、Murray, R. M.、Reveley, A. M.(1984)。Twin concordance for operationally defined schizophrenia. Confirmation of familiality and heritability。Archives of General Psychiatry，41，541-545。
64.	Kety, S. S.、Wender, P. H.、Jacobsen, B.(1994)。Mental illness in the biological and adoptive relatives of schizophrenic adoptees. Replication of the Copenhagen study in the rest of Denmark。Archives of General Psychiatry，51，442-455。
65.	胡海國、洪成志、Lee, Yi-Ling、Lee, Ping-Chuan、Lee, Sandy F. C.(1998)。Dopamine D4 receptor gene polymorphisms and neuroleptic response in schizophrenia。Biological Psychiatry，44，483-487。
66.	胡海國、林明薇、Lee, Ping-Chuan、Lee, Sandy F. C.、Ou-Yang, Wen-Chen、劉智民(2000)。Evaluation of linkage of markers on chromosome 6p with schizophrenia in Taiwanese families。American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics，96(1)，74-78。
67.	楊延光、葉宗烈(2002)。環境、腦與人類行為。臺灣醫界，45(3)，36-40。延伸查詢
68.	Krebs, E. G.(1989)。Role of the cyclic AMP-dependent protein kinesis in signal transudation。JAMA: The Journal of the American Medical Association，262，1815-1818。
69.	Sheng, M.、Greenberg, M. E.(1990)。The regulation and function of c-fos and other immediate early genes in the nervous system。Neuron，4，477-485。
70.	Morgan, J. I.、Curran, T.(1991)。Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun。Annual Review of Neuroscience，14，421-451。
71.	Deutch, A. Y.(1992)。The regulation of subcortical dopamine systems by the prefrontal cortex: Interactions of central dopamine systems and the pathogenesis of schizophrenia。Journal of Neural Transmission，36，61-89。
72.	Gray, J. A.(1998)。Integrating schizophrenia。Schizophrenia Bulletin，24，249-266。
73.	Heaton, R. K.、Gladsjo, J. A.、Palmer, B. W.、Kuck, J.、Marcotte, T. D.、Jeste, D. V.(2001)。Stability and course of neuropsychological deficits in schizophrenia。Archives of General Psychiatry，58，24-32。
74.	Lamentia, A. S.(1999)。Forebrain Induction, retinoic acid, vulnerability to schizophrenia: Insight from molecular and genetic analysis in developing mice。Biological Psychiatry，46，19-30。
75.	陳嘉祥、Chiu, Y. L.、Shaw, C. K.、Tsai, M. T.、Hwang, A. L.、Hsiao, K. J.(1999)。Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers。Molecular Psychiatry，4，566-571。

圖書
1.	Grebb, J. A.、Kaplan, H. I.、Sadock, B. J.(1994)。Synopsis of Psychiatry。Baltimore, MD：Williams ＆ Wilkins。
2.	林憲(1978)。精神醫學與社會。臺北：當代醫學雜誌社。延伸查詢
3.	Chang, W. H.、胡海國(1997)。Plasma HVA Studies in Schizophrenia: Implications for Dopamine Dysfunction。Plasma Homovanillic Acid in Schizophrenia: Implications for Presynaptic Dopamine Dysfunction。Washington, DC。
4.	Carlssom, A.(1995)。The dopamine theory revisited。Schizophrenia。Oxford。
5.	Schneider, K.(1959)。Clinical psychopathology。New York, NY：Grune and Stratton。
6.	葉英堃、Rin, H.、林宗義(1969)。Mental disorder in Taiwan fifteen years later。Mental Health Research in Asia and the Pacific。Hawaii, USA。
7.	Goldman-Rakic, P. S.、Feredman, H. R.(1991)。The circuitry of working memory revealed by anatomy and metabolic imaging。Frontal Lobe Function and Dysfunction。New York, NY。
8.	Gordon, M. F.(2000)。Normal Child Development。Kaplan's & Sadock's Comprehensive Textbook of Psychiatry。Boltimore。

其他
1.	Wang, S. M.，Yang, Y. K.，Yeh, T. L.。Regional cerebral blood flow and negative symptom in patients with schizophrenia，0。
2.	Chou, Y. H.，Halldin, C.，Farde, L.。PET characterization of LU201640 binding to D3 dopamine receptors in the monkey brain，0。
3.	Liao, Y. C.，Yang, Y. K.，Chen, P. C.。Socioeconomic cost in patients with schizophrenia in Taiwan，0。
4.	Chou, Y. H.，Halldin, C.，Farde, L.。PET characterization of LU201640 binding to D3 dopamine receptors in the monkey brain，0。

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