5HTT-VNTR基因多型性影響重度憂鬱症患者的長程聽覺誘發波N100、P200的組成_

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題名：	5HTT-VNTR基因多型性影響重度憂鬱症患者的長程聽覺誘發波N100、P200的組成
書刊名：	臺灣精神醫學
作者：	陳泰瑞／陳明招／余伍洋／張鈺姍
作者(外文)：	Chen, Tai-jui／Chen, Ming-chao／Yu, Younger W. Y.／Chang, Yu-san
出版日期：	2003
卷期：	17:3
頁次：	頁206-214
主題關鍵詞：	聽覺誘發波；重度憂鬱症；5HTT-VNTR基因多型性；Auditory evoked potentials；N100,P200；Major depressive disorder；5HTT-VNTR polymorphism
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:4 點閱:49

　　　　　目的：血清素系統被證實對聽覺誘發波N100 及P200 的組成有關，另有研究顯示聽覺誘發波的產生有遺傳性因素存在。血清素載具(serotonin transporter) 是突觸間隙的血清素再攝回突觸前神經元的主要工具，而該基因有一縱排重複變異數目區段被認為會影響轉譯的能力。本研究檢測5HTT-VNTR 基因多型性對重度憂鬱症患者聽覺誘發波N100、P200組成的影響。方法：本研究收集133個未曾治療的重度憂鬱症病患，在使用藥物治療前施與長程聽覺誘發波N100、P200與5HTT-VNTR基因多型性的檢測。結果：結果發現12/12 基因型比非12/12 基因型有較短的N100、P200 潛值與較大的N100 振幅。結論：我們的研究發現5HTT-VNTR 基因多型性影響重度憂鬱症患者聽覺誘發波N100、P200 的組成。

以文找文

　　　　　Objectives: Heritability has also been shown to be involved in the genesis ofAEP components. A role ofserotonergic system has been implicated in the NIOO and P200 components of auditory evoked potentials (AEPs) . The serotonin transporter is the major site of serotonin reuptake into the presynaptic neuron and it has been determined that two polymorphisms of the serotonin transporter (5HTT-LPR, serotonin transporter-linked polymorphism region; 5HTT-VNTR, variable number tandem repeat polymorphism in intron 2 of the serotonin transporter gene) may affect transcriptional activity. This study tested the hypothesis that 5HTT-VNTR genetic polymorphism affects the Nl and P2 components of AEPs. Methods: A total of 133 patients with major depressive disorder who were naive to treatment with SSRIs were enrolled. NIOO and P200 components ofAEPs were tested prior the administration SSRIs medications. Testing for 5HTT-VNTR genetic polymorphism was performed with standard PCR procedures. Results: Patients with the 12/12 genotype had a significantly shorter NIOO, P200 latency and larger NIOO amplitude compared with non-12/12 genotype carriers. Conclusion: The results of this study suggest that 5HTT-VNTR polymorphism affects the NIOO andP200 components of AEPs in patients with major depressive disorder.

以文找文

期刊論文
1.	陳純誠(20010300)。重鬱症生理病理機轉。臺灣精神醫學，15(1)，3-14。延伸查詢
2.	Ebstein, R. P.、Novick, O.、Umansky, R.、Priel, B.、Osher, Y.、Blaine, D.(1996)。Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking。Nature Genetics，12(1)，78-80。
3.	Lindsey, P. N.、Bauer, T. W.、Squires, K. C.、Hillyard, S. A.(1971)。Evoked Potential Correlates of Auditory Signal Detection。Science，172，1357-1360。
4.	Serretti, A.、Macciardi, F.、Verga, M.、Cusin, C.、Pedrini, S.、Smeraldi, E.(1998)。Tyrosine Hydroxylase Gene Associated with Depressive Symptomatology in Mood Disorder。American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics，81(2)，127-130。
5.	Serretti, A.、Cusin, C.、Lattuada, E.、Di Bella, D.、Catalano, M.、Smeraldi, E.(1999)。Serotonin Transporter Gene (5-HTTLPR) Is Not Associated with Depressive Symptomatology in Mood Disorders。Molecular Psychiatry，4(3)，280-283。
6.	陳泰瑞、陳明招、成和玲、余伍洋(2002)。未接受過治療重度憂鬱症患者長程聽覺誘發波之變化。臺灣精神醫學，16(1)，58-66。延伸查詢
7.	余伍洋、蔡世仁、陳泰瑞、林清華、洪成志(2002)。Association Study of the Serotonin Transporter Promoter Polymorphism and Symptomatology and Antidepressant Response in Major Depressive Disorders。Molecular psychiatry，7(10)，1115-1119。
8.	Juckel, G.、Molnar, M.、Hegerl, U.、Csepe, V.、Karmos, G.(1997)。Auditory-evoked Potentials as Indicator of Brain Serotonergic Activity - First Evidence in Behaving Cats。Biological Psychiatry，41(12)，1181-1195。
9.	Van Beijsterveldt, C. E.、Boomsma, D. I.(1994)。Genetics of the Human Electroencephalogram (EEG) and Event-related Brain Potentials (ERPs): A Review。Human Genetics，94(4)，319-330。
10.	O'Connor, S.、Morzorati, S.、Christian, J. C.、Li, T. K.(1994)。Heritable Features of the Auditory Oddball Event-related Potential: Peaks, Latencies, Morphology and Topography。Electroencephalography and Clinical Neurophysiology，92(2)，115-125。
11.	Noble, E. P.、Berman, S. M.、Ozkaragoz, T. Z.、Ritchie, T.(1994)。Prolonged P300 Latency in Children with the D2 Dopamine Receptor A1 Allele。American Journal of Human Genetics，54(4)，658-668。
12.	Blum, K.、Braverman, E. R.、Dinardo, M. J.、Wood, R. C.、Sheridan, P. J.(1994)。Prolonged P300 Latency in A Neuropsychiatric Population with the D2 Dopamine Receptor A1 Allele。Pharmacogenetics，4(6)，313-322。
13.	Johnson, J. P.、Muhleman, D.、MacMurray, J.、Gade, R.、Verde, R.、Ask, M.、Kelley, J.、Comings, D. E.(1997)。Association between the Cannabinoid Receptor Gene (CNR1) and the P300 Event-related Potential。Molecular psychiatry，2(2)，169-171。
14.	Hill, S. Y.、Locke, J.、Zezza, N.、Kaplan, B.、Neiswanger, K.、Steinhauer, S. R.、Wipprecht, G.、Xu, J.(1998)。Genetic Association between Reduced P300 Amplitude and the DRD2 Dopamine Receptor A1 Allele in Children at High Risk for Alcoholism。Biological Psychiatry，43(1)，40-51。
15.	Comings, D. E.、Dietz, G.、Johnson, J. P.、MacMurray, J. P.(1999)。Association of the Enkephalinase Gene with Low Amplitude P300 Waves。Neuroreport，10(11)，2283-2285。
16.	Ratsma, J. E.、Van Der Stelt, O.、Schoffelmeer, A. N.、Westerveld, A.、Boudewijn Gunning, W.(2001)。P3 Event-related Potential, Dopamine D2 Receptor A1 Allele, and Sensation-seeking in Adult Children of Alcoholics。Alcoholism, Clinical and Experimental Research，25(7)，960-967。
17.	林清華、余伍洋、陳筱萍、蔡世仁、洪成志(2001)。Association Analysis for Dopamine D2 Receptor Taq1 Polymorphism with P300 Event-related Potential for Normal Young Females。Psychiatric Genetics，11(3)，165-168。
18.	Winterer, G.、Smolka, M.、Smochowiec, J.、Mulert, C.、Ziller, M.、Mahlberg, R.、Wuebben, Y.、Gallinat, J.、Rommelspacher, H.、Herrman, W. M.、Sander, T.(2000)。Association Analysis of GABAAbeta2 and Gamma2 Gene Polymorphisms with Event-related Prefrontal Activity in Man。Human Genetics，107(5)，513-518。
19.	余伍洋、蔡世仁、楊寬弘、林清華、陳明招、洪成志(2001)。Evidence for an Association between Polymorphism in the Serotonin-2A Receptor Variant (102T/ C) and Increment of N100 Amplitude in Schizophrenics Treated with Clozapine。Neurop-sychobiology，43(2)，79-82。
20.	陳泰瑞、余伍洋、陳明招、蔡世仁、洪成志(2002)。Association Analysis for Serotonin Transporter Promoter Polymorphism and Auditory Evoked Potentials for Major Depression。Neuropsychobiology，46(2)，57-60。延伸查詢
21.	Coffman, J. A.、Torello, M. W.、Lewis, C. E.、Fortin, L. D.、Martin, D. J.(1989)。Event-related Brain Potentials in Depressed Patients Treated with Electroconvulsive Therapy。Progress in Neuro-psychopharmacology & Biological Psychiatry，13(5)，687-692。
22.	Pantev, C.、Hoke, M.、Lehnertz, K.、Lutkenhoner, B.、Fahrendorf, G.、Stober, U.(1990)。Identification of Sources of Brain Neuronal Activity with High Spatiotemporal Resolution Through Combination of Neuromagnetic Source Localization (NMSL) and Magnetic Resonance Imaging (MRI)。Electroencephalography and Clinical Neurophysiology，75(3)，173-184。
23.	Brown, R. M.、Crane, A. M.、Goldman, P. S.(1979)。Regional Distribution of Monoamines in the Cerebral Cortex and Subcortical Structures of the Rhesus Monkey: Concentrations and in Vivo Synthesis Rates。Brain Research，168(1)，133-150。
24.	Van Leeuwen, T. H.、Verbaten, M. N.、Koelega, H. S.、Slangen, J. L.、Van Der Gugten, J.、Camfferman, G.(1995)。Effects of Oxazepam on Event-related Brain Potentials, EEG Frequency Bands, and Vigilance Performance。Psychopharmacology，122(3)，244-262。
25.	D'Ardhuy, X. L.、Boeijinga, P. H.、Renault, B.、Luthringer, R.、Rinaudo, G.(1999)。Effects of Serotonin-selective and Classical Antidepressants on the Auditory P300 Cognitive Potential。Neuropsychobiology，40(4)，207-213。
26.	Battersby, S.、Ogilvie, A. D.、Smith, C. A.、Blackwood, D.H.、Muir, W. J.、Quinn, J. P.、Fink, G.、Goodwin, G. M.、Harmar, A. J.(1996)。Structure of A Variable Number Tandem Repeat of the Serotonin Transporter Gene and Association with Affective Disorder。Psychiatric Genetics，6(4)，177-181。
27.	Heils, A.、Teufel, A.、Petri, S.、Seemann, M.、Bengel, D.、Balling, U.、Riederer, P.、Lesch, K. P.(1995)。Functional Promoter and Polyadenylation Site Mapping of the Human Serotonin (5-HT) Transporter Gene。Journal of Neural Transmission. General Section，102(3)，247-254。
28.	MacKenzie, A.、Quinn, J.(1999)。A Serotonin Transporter Gene Intron 2 Polymorphic Region, Correlated with Affective Disorders, Has Allele-dependent Differential Enhancer-like Properties in the Mouse Embryo。Proceedings of the National Academy Sciences of the United States of America，96(26)，15251-15255。
29.	蔡世仁、歐陽文貞、洪成志(2002)。Association for Serotonin Transporter Gene VNTR Polymorphism and Schizophrenic Disorders。Neuropsychobiology，45(3)，131-133。
30.	劉萬清、顧牛范、馮國鄞、張健剛、李勝、柏邵春、沈稻、David, St. C.、賀林(1998)。Association of VNTR Region of the Human Serotonin Transporter Gene with Bipolar Disorder among the Han Chinese。中華醫學遺傳學雜誌，15(6)，345-348。延伸查詢
31.	Benjamin, J.、Li, Lin、Patterson, C.、Greenberg, B. D.、Murphy, D. L.、Hamer, D. H.(1996)。Population and Familial Association between the D4 Dopamine Receptor Gene and Measures of Novelty Seeking。Nature Genetics，12，81-84。
32.	Lesch, K. P.、Bengel, D.、Heils, A.、Sabol, S. Z.、Greenberg, B. D.、Petri, S.、Benjamin, J.、Muller, C. R.、Hamer, D. H.、Murphy, D. L.(1996)。Association of Anxiety-related Traits with A Polymorphism in the Serotonin Transporter Gene Regulatory Region。Science，274(5292)，1527-1531。
33.	Ho, L. W.、Furlong, R. A.、Rubinsztein, J. S.、Walsh, C.、Paykel, Eugene S.、Rubinsztein, D. C.(2000)。Genetic Associations with Clinical Characteristics in Bipolar Affective Disorder and Recurrent Unipolar Depressive Disorder。American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics，96(1)，36-42。
34.	Gorwood, P.、Batel, P.、Ades, J.、Hamon, M.、Boni, C.(2000)。Serotonin Transporter Gene Polymorphisms, Alcoholism, and Suicidal Behavior。Biological Psychiatry，48(4)，259-264。
35.	Bellivier, F.、Szoke, A.、Henry, C.、Lacoste, J.、Bottos, C.、Nosten-Bertrand, M.、Hardy, P.、Rouillon, F.、Launay, J. M.、Laplanche, J. L.、Leboyer, M.(2000)。Possible Association between Serotonin Transporter Gene Polymorphism and Violent Suicidal Behavior in Mood Disorders。Biological Psychiatry，48(4)，319-322。
36.	Serretti, A.、Macciardi, F.、Cusin, C.、Lattuada, E.、Lilli, R.、Smeraldi, E.(1998)。Dopamine Receptor D4 Gene Is Associated with Delusional Symptomatology in Mood Disorders。Psychiatry Research，80(2)，129-136。

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