In terms of the significance of scientific learning in general college education, the author’s ideology is that the teaching of science should play a role in educating college graduates as rational intellectuals in the science and technology-oriented present, as well as the near future. Therefore, the evolution of goals in science education both in the United States and Taiwan, at the pre-tertiary level, were first discussed, followed by an introduction and elaboration of the essence and educational implications of the Science / Technology /Society (STS) rationale. Lastly, an issue oriented model (IMO) was proposed as one of the strategies for teaching science in college, in helping college students to develop multi-dimensional science literacy. This researcher hopes the IMO will be implemented in the classroom context and critiqued in terms of student achievement and feed back.