Fire scene reconstruction helps investigators with identifying where the fire occurs. The purpose of fire scene simulation, using Computation Fluid Dynamic code, is to provide evidence for fire investigation. Describing the configuration of fuel, effects of ventilation, designation of the building, the impact of manual or automatic extinguishments and fire source help the reproduction of fire scene by simulation method. Simulations can reconstruct fire processes and explain fire development and smoke movement. Comparing simulation results with actual events, we can get clear evidence toward the fire and smoke development. This paper used FDS 4.0.5 to simulate a hotel fire in Taiwan using parallel processing method. Its results demonstrated god predication of the fire development and smoke movement by comparing with the combustion evidences of the scene and evacuees' description. This article also provided application of fire simulation into actual fire scene investigation. Fire dynamic simulator, developed by NIST/BFEL, used to simulated fire scene in this research. To understand the accuracy and rationality of the simulation, comparing real burned house with simulation hopes to estimate the feasibility of theories model applying into actual fire scene investigation.