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題名：藥物不良反應報告：疑似L-Asparaginase引起的急性壞死性胰臟炎
書刊名：臺灣臨床藥學雜誌
作者：蔡佳靜／馮靜修
作者(外文)：Tasi, Chia-ching／Feng, Ching-hsiu
出版日期：2005
卷期：13:2
頁次：頁101-109
主題關鍵詞：Asparaginase；急性壞死性胰臟炎；胰臟炎；藥品不良反應；L-Asparaginase；Acute necrotizing pancreatitis；pancreatitis；Adverse drug reaction
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L-Asparaginase (ASP)為治療兒童急性淋巴母細胞白血病(acute lymphoblastic leukemia; ALL)和T-Cell malignant lymphoma的重要治療用藥，它的有效及重要性已被確立，但是ASP有些不良反應雖然究見但卻足以致命。本文提出此案例為2歲女孩，以ASP與vincristine, epirubicin, steroid治療ALL。在完成緩解誘導期後，引起急性壞死性胰臟炎而入院治療，治療包括手術、放置鼻胃管抽吸、禁食給予TPN、矯正電解質異常、控制血糖、治療感染、並給予octreotide等。在情形穩定後轉回臺北馬偕繼續化學治療，目前此患者已回到本院追蹤治療，但仍需以胰島素控制血糖。
l-Asparaingase (ASP) is a useful antileukemic agent for childhood acute lymphoblastic leukemia (ALL) and T-Cell malignant lymphoma. Its effectiveness and importance have been established, but there are some adverse reactions, which are rare but severe enough to cause fatality. We reported a 2-year-old girl who was the victim of ALL was treated with ASP combination with vincristine, epirbubicin, and steroid. She was admission again, which induced acute necrotizng pancreatitis after complete remission therapy. During the hospitalization, she was treated with aggressive support therapy including surgery, bowel rest, nasogastric suctioning, parenteral nutrition, corrected electrolytic imbalance, control blood sugar, control infection, and intravenous octreotide. When condition stabilized, she was transferred to Taipei MMH for continuing chemotherapy. Now, she is follow up on continuing blood sugar control with insulin.
期刊論文
1.Underwood, T. W.、Frye, C. B.(1993)。Drug-induced pancreatitis。Clin Pharm，12(6)，440-448。  new window
2.Eland, I. A.、van Puijenbroek, E. P.、Sturkenboom, M. J.(1999)。Drug-associated acute pancreatitis: twenty-one years of spontaneous reporting in the Netherlands。Am J Gastroenterol，94，241724-22。  new window
3.Ueda, K.(1999)。L-asparaginase: Side effects and prophylaxis measures。Jpn J Pediatr Hematol，13(2)，68-78。  new window
4.Shaw, M. T.、Barnes, C. C.、Madden, F. J.(1970)。L-asparaginase and pancreatitis。Lancet，2(7675)，721。  new window
5.Nguyen, D. L.、Wilson, D. A.、Engelman, E. D.(1987)。Serial sonograms to detect pancreatitis in children receiving L-Asparaginase。South Med J，80(9)，1133-1136。  new window
6.Adamson, R. H.、Fabro, S.(1968)。Antitumor activity and other biologic properties of L-asparaginase。Cancer Chemother. Rep，52(6)，617-626。  new window
7.Haskell, C. M.、Canellos, G. P.、Leventhal, B. G.(1969)。L-asparaginase: therapeutic and toxic effects in patients with neoplastic disease。N Engl J Med，281(19)，1028-1034。  new window
8.Alvarez, O. A.、Zimmerman, G.(2000)。Pegaspargase-induced pancreatitis。Med Pediatr Oncol，34(3)，200-205。  new window
9.Sahu, S.、Saika, S.、Pai, S. K.(1998)。L-Asparaginase (Leunase) induced pancreatitis in childhood acute lymphoblastic leukemia。Pediatr Hematol Oncol，15，533-538。  new window
10.Weetman, R. M.、Baehner, R. L.(1974)。Latent onset of clinical pancreatitis in children receiving L-Asparaginase therapy。Cancer，34，780-785。  new window
11.Loeb, E.、Hill, J. M.、Hill, N. O.(1970)。Treatment of acute leukemia with L-asparaginase。Recent Results Cancer Res，33，204-218。  new window
12.Garrington, T.、Bensard, D.、Ingram, J. D.(1998)。Successful management with octreotide of a child with L-asparaginase induced hemorrhagic pancreatitis。Med Pediatr Oncol，30(2)，106-109。  new window
13.Cheung, Y. B.、Lee, C. W.、Chan, C. F.(1994)。Somatostatin therapy in L-asparaginase-induced pancreatitis。Med Pediatr Oncol，22(6)，421-424。  new window
14.Harris, A. G.(1994)。Somatostatin and somatostatin analogues: pharmacokinetics and pharmacodynamic effects。Gut，35(Suppl3)，1-4。  new window
15.Lam, J. C.、Aters, S.、Tobias, J. D.(2001)。Initial experience with octreotide in the pediatric population。Am J Ther，8(6)，409-415。  new window
 
 
 
 
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