困難傷口帶來的困擾及其未知性，不但限制病人的日常活動，更使得病人生活品質受到損害；高壓氧氣治療對困難傷口，可提高組織的含氧量，增加細胞修復功能與傷口康復的機率，以助改善病人的生活品質，故本研究主要目的是探討高壓氧氣治療對困難傷口病人生活品質之成效。此研究為縱斷式前瞻性研究，採立意取樣方式，對象為某醫學中心接受高壓氧氣治療病人計15人，在接受高壓氧氣治療前、後，分別利用問卷蒐集資料，問卷包括個人基本特性、自覺傷口嚴重度、傷口生氣指標及生活品質量表，結果顯示：(1)研究對象的整體生活品質，在高壓氧氣治療後比治療前的得分高(20.75分 > 17.56分)；(2)高壓氧氣治療後之困難傷口病人的生活品質與Strauss傷口分類系統呈現正相關；(3)高壓氧氣治療後之困難傷口病人的生活品質與自覺傷口嚴重度呈現負相關。藉由結果對護理實驗及研究等方向提出建議，以期有效協助高壓氧氣治療之困難傷口病人獲得滿意的生活品質。

The unpredictable course followed by severe, chronic, non-healing wounds not only restricts the daily activities of affected patients, but also impairs their quality of life (QOL). Hyperbaric oxygen therapy (HBOT) treatment for such wounds elevates tissue oxygen content, increases cellular repair functions and the probability of wound healing, and improves the patient’s QOL. This was a longitudinal, prospective study, and used a purposive sampling method. A total of 15 patients receiving HBOT at a medical center were enrolled. Data were collected by questionnaire before and after HOBT. The questionnaire included basic patient characteristics, self-perceived wound severity, wound physiological indices, and a QOL scale. The overall QOL score of the subjects after HBOT was higher than before HBOT. After HBOT, there was a positive correlation between the QOL of patients with problem wounds and the scoring of the Strauss wound classification system. After HBOT, there was a negative correlation between the QOL of patients with problem wounds and their self-perceived severity of the wound. The results were then used to provide suggestions for nursing care and additional research directions in order to effectively assist patients with problem wounds receiving HBOT, with the goal of achieving an optimal QOL.