低劑量L-Name與耐力性運動訓練對大鼠肝醣儲存的影響__臺灣人文及社會科學引文索引資料庫

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題名：	低劑量L-Name與耐力性運動訓練對大鼠肝醣儲存的影響
書刊名：	成大體育
作者：	蘇易廷／林嘉志／謝伸裕
出版日期：	2006
卷期：	39:3=50
頁次：	頁26-35
主題關鍵詞：	一氧化氮；耐力性運動訓練；肝醣；骨骼肌；NO；Endurance training；Glycogen；Skeletal muscle；L-NAME
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:0 點閱:25

　　目的：觀察低劑量一氧化氣合成時非選擇性抑制劑L-NAME 與耐力性運動訓練對大鼠骨骼肌肝醣與肝臟肝醣的影響。方法：23隻Wistar品系六週齡公鼠隨機分為四組：Control組（n=6），L-NAME組（n=6），Exercise組（n=6）及L-NAME + Exercise組（n=5）。大鼠的耐力訓練方式以原地跑步機進行五週：由第一週15 公尺／分鐘（18分鐘）逐漸增強至第五週為24公尺／分鐘（60 分鐘）。L-NAME（5 毫克／公斤／日，5 天／週）的餵食則在運動訓練前一小時完成。測量項目包括平均動脈壓、比目魚肌檸檬酸合成酶活性、腓腸紅肌與比自魚肌及肝臟之肝醣。統計方法以獨立樣本雙因子變異數分析檢定，顯著水準至少須達p≦.05 。測量數據以平均數±標準誤表示。結果:耐力運動訓練及低劑量L-NAME 對大鼠平均動脈壓及腓腸肌白肌肝醣含量緣無顯著影響（p>.05），但耐力運動訓練能顯著增加檸檬酸合成酶活性、腓腸紅肌與比目魚肌肝醣及肝臟肝醣含量（p<.001），而低劑量L-NAME 亦能顯著增加霏腸肌紅肌肝醣含量（p<.05），並顯著降低肝臟肝醣含量（p<.05）。結論：耐力運動訓練能增加骨骼肌紅肌肝醣含量及檸檬酸合成酶活性，低劑量L-NAME 則對骨骼肌紅肌肝醣含量有加成的影響，並降低肝臟肝醣含量，顯示低劑量L-NAME能影響肝醣儲存的位置。

以文找文

　　PURPOSE: To investigate the effects of low-dosage L-NAME and endurance training on skeletal muscle and liver glycogen storage in rats. METHODS: Twenty-three male Wistar rats (6-week old) were randomly divided into four groups: Control (n = 6), L-NAME (n = 6), Exercise (n = 6) and L-NAME + Exercise (n = 5). Rats were training on treadmill at a belt speed 15 m/min for 18 min during the 1st week, and increased to 24 m/min for 60 min during the 5th week. L-NAME(5 mg/kg/day, 5 days/wk) was fed one hour before the training. After 5 wks, rats were analyzed for mean blood pressure, citrate synthase activity(CS), and the glycogen contents of soleus, gastrocnemius and liver. Independent 2×2 ANOVA was used to evaluate the mean difference. The significance was set at p ~ .05. Data were expressed at MEAN ± SEM. RESULTS: The analysis indicated mean blood pressure and the glycogen content of gastrocnemius white muscle was not significantly affected in endurance trained rats and L-NAME treated rats(p> .05), but CS activity and glycogen content of gastrocnemius red muscle, soleus muscle and liver was significant enhanced in endurance trained rats (p < .001). Also, gastrocnemius red muscle glycogen in L-NAME treated rats were significantly increased(p <.05), Analysis also shows L-NAME treatment significantly decreased liver glycogen (p < .05). CONCLUSION: Endurance training could increase skeletal red muscle glycogen content and CS activity of rat. Low-dose L-NAME treatment could increase skeletal red muscle but decrease liver glycogen content in endurance trained rat. It is evident that low-dose L-NAME treatment could affect the location of storage.

以文找文

期刊論文
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