This article describes our nursing experiences applied to the Roy's adaptation model for a woman with myoma, receiving hysterectomy. The period of nursing care was from January 6th to 11th in 2006. Data was collected through observations, interviews, physical examinations and phone-communications. Four nursing diagnosis were identified including acute pain, deficient knowledge/ specifically in the use of hormone, disturbed self-concept, and ineffective sexuality pattern. Individual nursing interventions used included promoting comfort, adaptation to the postoperative life, reestablishing a positive self-concept, and self-confidence, and learning proper sexual knowledge, in order to achieve the physical and psychological well-being. The author hopes this case report will provide a useful reference to nurses charged with caring for women with hysterectomy.