Objective: The present case report demonstrates the efficacy of non-pharmacological strategies, namely positional therapy and cognitive behavior therapy (CBT), in the management of insomnia and sleep apnea symptoms in patients with obstructive sleep apnea comorbid with insomnia. Method: The patient was a 47-year-old male with a chief complain of insomnia and snoring, and was diagnosed with a severe sleep apnea syndrome. Positional therapy was introduced to reduce sleep apnea by having the patient wear night clothes with two golf balls stitched on its back, in order to keep a lateral sleep position. In addition, CBT for insomnia was applied with the following components: stimulus control instruction, sleep restriction therapy, relaxation training, and sleep hygiene education to eliminate his insomnia. Sleep diary and polysomnography (PSG) were used to evaluate the patient's progress and treatment effects. Results: The treatment consisted of nine weekly 50-minutes individual sessions. The patient's sleep apnea and insomnia symptoms were improved significantly after treatment. Respiratory disturbance index decreased from 34.3/hr to 7.6/hr, PSG sleep onset latency decreased from 12.5min. to 4 min., subjective sleep latency decreased from 55min. to 15min., and average sleep time increased from 4.9hrs to 6.9hrs. The ratings on both quality of sleep and daytime alertness improved from 3.67 points to 4 points. Conclusion: Positional therapy in combination with CBT for insomnia can improve position-related obstructive sleep apnea symptoms and associated insomnia. Because these non-pharmacological strategies are safe, inexpensive, and can be conducted relatively easily, they could be the treatment of choice for patients with insomnia complaints associated with position-related sleep apnea.