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題名：以激效作用觀點探討運動之抗老化機轉
書刊名：運動生理暨體能學報
作者：林嘉志／姚承義 引用關係
作者(外文)：Lin, Chia-chih／Yau, Chern-yu
出版日期：2006
卷期：5
頁次：頁61-69
主題關鍵詞：激效作用；運動；抗老化；Hormesis；Exercise；Anti-aging
原始連結：連回原系統網址new window
相關次數：
  • 被引用次數被引用次數:期刊(7) 博士論文(1) 專書(0) 專書論文(0)
  • 排除自我引用排除自我引用:6
  • 共同引用共同引用:0
  • 點閱點閱:97
激效作用(hormesis)觀念近來愈見被重視用於解釋遺傳及環境因子抗老化益處的機轉。本文特以激效作用闡明運動抗老化的可能機轉。因運動所產生的活性氧物質(reactive oxygen species, ROS)與開展蛋白(unfolded protein)為刺激抗氧化系統、伴護蛋白、受損分子移除及修復系統、神經滋養因子、抗衰老因子等基因或功能表現的上游分子，在適量時才能發揮良性刺激促成上述現象。活性氧物質的累積與許多神經退化性疾病有密切關係，預防的方式除了規律運動外，還包括控制活性氧物質在人體體內含量，例如限制能量攝取(energy restriction)與認知刺激(cognitive stimulation)等因素。能達到激效作用的活性氧物質劑量為，降低總產生量並微增至足以有效清除的劑量，這也是目前對活性氧物質含量與生理反應看似模糊關係較合理的解釋。未來研究應進一步證實引起活性氧物質的產生是否只是運動與過量能量攝取的共同機轉，而運動對神經細胞的刺激尚能與其他調控神經保護因子的上游訊息傳遞路徑尚有複雜的交互作用。
The concept of hormesis has been increasingly recognized as a mechanism underlying the beneficial anti-aging effect of certain genetic and environmental factors. This review article elucidates possible mechanisms of anti-aging effect of exercise through hormesis hypothesis. The reactive oxygen species (ROS) and unfolded proteins produced by exercise, which play an important role on the expression of anti-oxidative system, protein chaperon, removing system and repair system of damaged molecules, exert a beneficial stimulation only when the dose is adequate. The accumulation of ROS correlates closely with degenerative neuron diseases. Besides regular exercise, other ways to prevent detrimental effect of ROS including energy restriction and cognitive stimulation. The optimal ROS dose which can achieve hormesis is decreased total ROS generation and intermittently increased to scavenge ROS efficiently. So far, this has been the reasonable explanation to argue the obscure relationship between the ROS dose and physiological response. The future challenge is to clarify if ROS generation is the common pathway between exercise and excess energy uptake and complicated cross-talk exists between oxidative stimuli from exercise and upstream regulators of neuroprotective facto.rs
期刊論文
1.Andrade, F. H.、Reid, M. B.、Westerblad, H.(2001)。Contractile response of skeletal muscle to low peroxide concentrations: myofibrillar calcium sensitivity as a likely target for redox-modulation。The FASEB Journal，15(2)，309-311。  new window
2.Arumugam, T. V.、Gleichmann, M.、Tang, S. C.、Mattson, M. P.(2006)。Hormesis/preconditioning mechanisms, the nervous system and aging。Ageing Research Review，5(2)，165-178。  new window
3.Barger, J. L.、Walford, R. L.、Weindruch, R.(2003)。The retardation of aging by caloric restriction; its significance in the transgenic era。Experimental Gerontology，38(11/12)，1343-1351。  new window
4.Calabrese, E. J.、Baldwin, L. A.(2002)。Defining hormesis。Human & Experimental Toxicology，21(2)，91-97。  new window
5.Calabrese, E. J.、Baldwin, L. A.(2003)。Ethanol and hormesis。Critical Reviews in Toxicology，33(3/4)，407-424。  new window
6.Calabrese, E. J.、Baldwin, L. A.(2003)。Toxicology rethinks its central belief。Nature，421(6924)，691-692。  new window
7.DeGracia, D. J.、Montie, H. L.(2004)。Cerebral ischemia and the unfolded protein response。Journal of Neurochemistry，91(1)，1-8。  new window
8.Guarente, L.(2005)。Calorie restriction and SIR2 genes-towards a mechanism。Mechanisms of Ageing and Development，126(9)，923-928。  new window
9.Johnson, T. E.、Henderson, S.、Murakami, S.、de Castro, E.、de Castro, S. H.、Cypsert, J.(2002)。Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease。Journal of Inherited Metabolic Disease，25(3)，197-206。  new window
10.Kaiser, J.(2003)。Hormesis. A healthful dab of radiation?。Science，302(5644)，378。  new window
11.Katie, M,、Kahn, C. R.(2005)。The role of insulin and IGF-1 signaling in longevity。Cellular and Molecular Life Sciences，62(3)，320-343。  new window
12.Lazarov, O.、Robinson, J.、Tang, Y. P.、Hairston, I. S.、Korade-Mirnics, Z.、Lee, V. M. Y.、Sisodia, S. S.(2005)。Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice。Cell，120(5)，701-713。  new window
13.Lu, B(2003)。BDNF and activity-dependent synaptic modulation。Learning & Memory，10(2)，86-98。  new window
14.Mayeux, R.(2003)。Epidemiology of neurodegeneration。Annual Review of Neuroscience，26，81-104。  new window
15.Nagappan, G.、Lu, B.(2005)。Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications。Trends in Neurosciences，28(9)，464-471。  new window
16.Pani, G.、Colavitti, R.、Bedogni, B.、Anzevino, R.、Galeotti, T.、Borrello, S.(2000)。A redox signaling mechanism for density-dependent inhibition of cell growth。The Journal of Biological Chemistry，275(49)，38891-38899。  new window
17.Pirkkala, L.、Nykanen, P.、Sistonen, L.(2001)。Roles of the heat shock transcription factors in regulation of the heat shock response and beyond。The FASEB Journal，15(7)，1118-1131。  new window
18.Prolla, T. A.、Mattson, M. P.(2001)。Molecular mechanisms of brain aging and neurodegenerative disorders: lessons from dietary restriction。Trends in Neuroscience，24(11 Suppl)，S21-31。  new window
19.Radak, Z.、Chung, H. Y.、Goto, S.(2005)。Exercise and hormesis: oxidative stress-related adaptation for successful aging。Biogerontology，6(1)，71-75。  new window
20.Stebbing, A. R.(1982)。Hormesis-the stimulation of growth by low levels of inhibitors。The Science of the Total Environment，22(3)，213-234。  new window
21.Sun, J. Z.、Tang, X. L.、Park, S. W.、Qiu, Y.、Turrens, J. F.、Bolli, R.(1996)。Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs。The Journal of Clinical Investigation，97(2)，562-576。  new window
22.Thayer, K. A.、Melnick, R.、Burns, K.、Davis, D.、Huff, J.(2005)。Fundamental flaws of hormesis for public health decisions。Environmental Health Perspectives，113(10)，1271-1276。  new window
23.Tong, L.、Shen, H.、Perreau, V. M.、Balazs, R.、Cotman, C. W.(2001)。Effects of exercise on gene-expression profile in the rat hippocampus。Neurobiology of Disease，8(6)，1046-1056。  new window
24.Harman, D.(2003)。The free radical theory of aging。Antioxid Redox Signal，5(5)，557-561。  new window
其他
1.Biology-Online Team(2005)。Aging，http://www.biology-online.org/dictionary/Aging， 2006/07/29。  new window
 
 
 
 
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