As a kind of particular subject matter, poetic painting of Mao Zedong, started in 1950 times, is an important media which make traditional Chinese painting work be able to access to the mainstream society, has reflected the change of political structure and the cultural life in politicized social reality. Moreover, Mao Zedong's poetic painting is regarded as one of the innovations of the reform and development of Chinese painting in special era by Chinese painter. It revealed Chinese painting's rough course for existing and developing under the history condition of paramount politic and class while reflected a generation painter's varied efforts under the peculiar politics culture and social environment. Evidently, Fu Baoshi played an important role in such historic progress. He found the chance in Mao Zedong's poem word and broke traditional subject matter, which was a available method to achieve self-protection and continue his own artistic heart. He studied approach that can combine new skills and new subjects, achieving great success, which pointed a way for young artists. In this paper, taking Fu Baoshi's Mao Zedong poetic draws as example, I intend to analyze his exploration for development of Chinese painting in the fifties and sixties of the 20th century, to pursue the unique meaning on the development of Chinese painting history in the Middle period of the 20th century.