臺灣人文及社會科學引文索引資料庫系統

:::

詳目顯示

回上一頁
第 1 筆 / 總合 1 筆   第一頁 上一頁 下一頁 最後一頁
/1頁
題名：基因轉殖的超級耐力鼠：原理與分子機轉
書刊名：中華體育季刊
作者：林嘉志 引用關係／陸康豪
出版日期：2009
卷期：23:1=88
頁次：頁46-57
主題關鍵詞：磷酸烯醇丙酮酸羧激酶；基因轉殖；能量代謝
原始連結：連回原系統網址new window
相關次數：
  • 被引用次數被引用次數:期刊(1) 博士論文(0) 專書(0) 專書論文(0)
  • 排除自我引用排除自我引用:1
  • 共同引用共同引用:0
  • 點閱點閱:20
研究姿現，若以生物工程技術將某些與粒線體增生相關基因作人工基因轉殖，可使小鼠耐力運動表現能力提升與骨骼肌纖維轉類型轉換的現象。著名的例子包括磷酸烯醇丙酮酸羧激酶(phosphoenolpyruvate carboxykinase, PEPCK-C)、過氧化體增生子活化受體γ-輔活化子-lα(Peroxisome proliferators-activated receptor γ-coactivator-lα, PGC-lα)、過氣化體活化受體γ(Peroxisome proliferators-activated receptorδ, PPARδ)等。其中，磷酸烯醇丙酮酸羧激酶在基因轉殖鼠的骨骼肌表現不僅大幅提升小鼠耐力運動表現，寺命及繁殖能力都獲得延長，因此相當受到矚目。本文闡明前述三種基因在肌細胞內的角色、功能、分子機轉與關聯性。據此，讀者能清楚瞭解磷酸烯醇丙酮酸羧激酶能具有令人驚奇效果的理由：不僅促進肌細胞內三酸甘油酯的合成，有效提升粒線體克氏循環產能效率，增加的游離脂肪酸更致活粒線體增生的機轉。人工基囚轉殖技術將使吾人更清楚認識基因在細胞內的角色與功能，並有助於治療骨骼肌功能不良或相關病症。
期刊論文
1.Lin, J.、Wu, H.、Tarr, P. T.、Zhang, C. Y.、Wu, Z.、Boss, O.(2002)。Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres。Nature，418(6899)，797-801。  new window
2.Yan, Z.、Li, P.、Akimoto, T.(2007)。Transcriptional control of the Pgc-1 alpha gene in skeletal muscle in vivo。Exercise and Sport Sciences Reviews，35(3)，97-101。  new window
3.Gibala, M. J.、MacLean, D. A.、Graham, T. E.、Saltin, B.(1997)。Anaplerotic processes in human skeletal muscle during brief dynamic exercise。The Journal of Physiology，502(3)，703-713。  new window
4.Dohm, G. L.、Patel, V. K.、Kasperek, G. J.(1986)。Regulation of muscle pyruvate metabolism during exercise。Biochemical Medicine and Metabolic Biology，35(3)，260-266。  new window
5.Burgess, S. C.、Hausler, N.、Merritt, M.、Jeffrey, F. M.、Storey, C.、Milde, A.(2004)。Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase。The Journal of Biological Chemistry，279(47)，48941-48949。  new window
6.Chakravarty, K.、Cassuto, H.、Reshef, L.、Hanson, R. W.(2005)。Factors that control the tissue-specific transcription of the gene for phosphoenolpyruvate carboxykinase-C。Critical Reviews in Biochemistry and Molecular Biology，40(3)，129-154。  new window
7.Granner, D.、Andreone, T.、Sasaki, K.、Beale, E.(1983)。Inhibition of transcription of the phosphoenolpyruvate carboxykinase gene by insulin。Nature，505(5934)，549-551。  new window
8.Goto, M.、Terada, S.、Kato, M.、Katoh, M.、Yokozeki, T.、Tabata, I.、Shimokawa, T.(2000)。cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats。Biochemical and Biophysical Research Communications，274(2)，350-354。  new window
9.Hakimi, P.、Johnson, M. T.、Yang, J.、Lepage, D. F.、Conlon, R. A.、Kalhan, S. C.(2005)。Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism。Nutrition & Metabolism，33。  new window
10.Hakimi, P.、Yang, J.、Casadesus, G.、Massillon, D.、Tolentino-Silva, F.、Nye C. K.(2007)。Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse。The Journal of Biological Chemistry，282(45)，32844-32855。  new window
11.Hanson, R. W.、Patel, Y. M.(1994)。Phosphoenolpyruvate carboxykinase (GTP): The gene and the enzyme。Advances in Enzymology and Related Areas of Molecular Biology，69，203-281。  new window
12.Lamers, W. H.、Hanson, R. W.、Meisner, H. M.(1982)。cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei。Proceedings of the National Academy of Sciences of the United States of America，79(17)，5137-5141。  new window
13.McGee, S. L.、Hargreaves, M.(2006)。Exercise and skeletal muscle glucose transporter 4 expression: Molecular mechanisms。Clinical and Experimental Pharmacology & Physiology，33(4)，395-399。  new window
14.McKee, E. E.、Bentley, A. T.、Smith, R. M.、Jr.、Kraas, J. R.、Ciaccio, C. E.(2000)。Guanine nucleotide transport by atractyloside-sensitive and -insensitive carriers in isolated heart mitochondria。American Journal of Physiology，279(6)。  new window
15.Owen, O. E.、Kalhan, S. C.、Hanson, R. W.(2002)。The key role of anaplerosis and cataplerosis for citric acid cycle function。The Journal of Biological Chemistry，277(34)，30409-30412。  new window
16.Roden, M.(2004)。How free fatty acids inhibit glucose utilization in human skeletal muscle。News in Physiological Sciences，19，92-96。  new window
17.Scarpulla, R. C.(2002)。Nuclear activators and coactivators in mammalian mitochondrial biogenesis。Biochimica et Biophysica Acta，1-14。  new window
18.Utter, M. F.、Kurahashi, K.(1954)。Purification of oxalacetic carboxylase from chicken liver。The Journal of Biological Chemistry，207(2)，787-802。  new window
19.Wang, Y. X.、Lee, C. H.、Tiep, S.、Yu, R. T.、Ham, J.、Kang, H.(2003)。Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity。Cell，113(2)，159-170。  new window
20.Wang, Y. X.、Zhang, C. L.、Yu, R. T.、Cho, H. K.、Nelson, M. C.、Bayuga- Ocampo, C. R.(2004)。Regulation of muscle fiber type and running endurance by PPARdelta。PLoS Biology，2(10)。  new window
21.Wu, Z.、Puigserver, P.、Andersson, U.、Zhang, C.、Adelmant, G.、Mootha, V.(1999)。Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1。Cell，98(1)，115-124。  new window
22.Zimmer, D. B.、Magnuson, M. A.(1990)。Immunohistochemical localization of phosphoenolpyruvate carboxykinase in adult and developing mouse tissues。The Journal of Histochemistry and Cytochemistry，38(2)，171-178。  new window
圖書
1.魏正舒、吳明道、洪錦堂、趙崇義、Berg, J. M.、Tymoczko, J. L.、Stryer, L. S.(2004)。Stryer's生物化學。臺北市。  延伸查詢new window
2.Hanson, R. W.、Patel, Y. M.(1994)。P-enolpyruvate carboxykinase: The gene and the enzyme。New York。  new window
 
 
 
 
第一頁 上一頁 下一頁 最後一頁 top
QR Code
QRCODE

臺灣人文及社會科學引文索引資料庫

目前上線人數：908（臺灣：884，外國：24） ／ 本年度總使用人次：2625314 ／ 訪客人次（自102年09月）：68431170
國家圖書館著作權聲明 Copyright © 2013 All rights reserved.
本館地址: 100201臺北市中山南路20號． 本館地圖及交通資訊．
總機：(02)23619132．最佳瀏覽解析度為1024x768以上