This article presents a close engagement with the historian E.P. Thompson's reading of the artist and writer William Blake (1757-1827) in Witness Against the Beast (1993). In particular, the interest is in the way Thompson comes to a theological insight through his interaction with Blake (this article is therefore not a study of Blake himself). Thompson explores Blake's writings and art, his connections with radical Dissenting groups in London, the light that the archives of the Muggletonians shed on such groups, and the theological positions of these groups. This search leads Thompson to identify the radical possibilities of Paul's doctrine of justification by faith. In the hands of these groups, the doctrine became a radical antinomian position with both theological and political ramifications. Thompson's insight is not merely to have (re-)discovered these radical possibilities, but also to have come to the position that religion and politics are inescapably interwoven.