資料載入處理中...
臺灣人文及社會科學引文索引資料庫系統
:::
網站導覽
國圖首頁
聯絡我們
操作說明
English
行動版
(18.189.178.190)
登入
字型:
**字體大小變更功能,需開啟瀏覽器的JAVASCRIPT,如您的瀏覽器不支援,
IE6請利用鍵盤按住ALT鍵 + V → X → (G)最大(L)較大(M)中(S)較小(A)小,來選擇適合您的文字大小,
如為IE7以上、Firefoxy或Chrome瀏覽器則可利用鍵盤 Ctrl + (+)放大 (-)縮小來改變字型大小。
來源文獻查詢
引文查詢
瀏覽查詢
作者權威檔
引用/點閱統計
我的研究室
資料庫說明
相關網站
來源文獻查詢
/
簡易查詢
/
查詢結果列表
/
詳目列表
:::
詳目顯示
第 1 筆 / 總合 1 筆
/1
頁
來源文獻資料
摘要
外文摘要
引文資料
題名:
異氰酸作業過敏勞工白血球DQ1基因類型
書刊名:
勞工安全衛生研究季刊
作者:
熊映美
/
司徒惠康
/
石東生
/
蕭孟芳
/
郭育良
/
姚振文
作者(外文):
Chiung, Yin-mei
/
Sytwu, Hui-kang
/
Shih, Tung-sheng
/
Shaio, Men-faung
/
Kuo, Yu-lian
/
Yao, Chen-wen
出版日期:
2009
卷期:
17:4
頁次:
頁424-435
主題關鍵詞:
異氰酸
;
過敏
;
勞工
;
白血球基因
;
Isocyanates
;
Allergy
;
Worker
;
HLA gene
原始連結:
連回原系統網址
相關次數:
被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0)
排除自我引用:0
共同引用:0
點閱:89
本研究搜集來自泡棉、合成皮及樹脂等異氰酸鹽類作業勞工之冷凍血液檢體,抽取核酸,分析第二型組織複合物抗原中的人類白血球抗原(Human Leukocyte Antigen, HLA)基因型。並依據問卷訪視勞工自覺過敏症狀進行工作相關過敏分群,統計各基因與異氰酸鹽過敏疾病的相關性。以34種HLA DQ1高解析度基因類型引子,進行PCR反應。總共完成271位勞工之基因型分析,統計所有對偶基因出現率之結果顯示只有26種基因型出現。其中以DQ1 0301基因出現頻率最高,佔23.3%;DQ1 0502次之,出現頻率佔12.9%。與過敏較有關係的DQ1 0601以及DQ1 0503基因出現率分別約為5.0%及3.3%,有過敏症狀群的出現頻率顯著高於無過敏症狀群(X^2, p<0.05)。與工作有關過敏症狀依照其發生部位,分別將勞工分為呼吸道過敏、皮膚過敏及眼睛過敏三種類群,發現各群出現顯著相關之基因型不盡相同。各基因之勝算比經性別、年齡、暴露、年資及吸菸等項目校正後,結果顯示DQ1 0503與DQ1 0402引發工作引起呼吸道過敏為最高,分別為5.79與4.66。DQ1 0601與皮膚及眼睛症狀均呈現顯著相關,但校正後勝算比卻小於1,顯示異氰酸鹽類暴露量低的非暴露群中亦有上述過敏的個案,該基因不是關鍵性決定因素。DQ1 0503 基因型與工作場所的呼吸道過敏及喘鳴症狀有顯著相關,未校正之勝算比為4.31,校正後增為5.79,顯示該基因對異氰酸鹽類暴露引起之呼吸道過敏有重要影響。依據上述結果推論DQ1基因中0503、0402及0601等基因型對於異氰酸類誘發過敏免疫反應,具有重要的意義。
以文找文
This study extracted nucleic acid from frozen blood samples collected from isocyanate salts operating workers who worked in the foam, synthetic leather and resins factories, analyzing complex antigens type II organization of human leukocyte antigen (Human Leukocyte Antigen, HLA) genotypes. Based on a questionnaire which inquired into the workers' consciously work-related allergy symptoms, we divided the respondents into deferent groups then counted various genes and the isocyanate allergy disease's relevance. Using 34 DQ1 high-resolution genetic primers for PCR reaction. We completed a total of 271 workers of the genotype analysis. Statistics of occurrence rate of the allele told that only 26 genotypes showed up. Among them, DQ1 0301 had the highest frequency of accounting (23.3%) and DQ1 0502 second (12.9%). The genes which were more associated with allergic syndromes, DQ1 0601 and 0503, had occurrence rates of approximately 5.0% and 3.3% (X^2, p<0.05). The statistic results showed work-related allergic symptoms occurred in different parts of bodies, the relevant genotypes were also different. After adjusting for gender, age, exposure, years of service and smoking habit using logistic regression, DQ1 0503 and DQ1 0402 trigger respiratory allergies which caused by the working showed the highest odds ratio (OR) 5.79 and 4.66. DQ1 0601 with skin and eyes showed a significant correlation between the symptoms, but the OR after correction is less than 1. It shows that gene is not a key determinant in the above-mentioned cases of allergy of isocyanate sensitization. DQ1 0503 genotype and work-related wheezing symptoms were significantly associated uncorrected OR of 4.31 and the correction OR is 5.79, show the genetic impact on the respiratory allergies caused by isocyanates exposure. According to the above results, our study indicated that the DQ1 0503, 0402 and 0601 have important significance to isocyanate-induced allergic reactions.
以文找文
其他
1.
Tarlo SM, Liss G.M, Dias C, and Banks DE.(1997)。Assessment of the relationship between isocyanate exposure levels and occupational asthma。
2.
Tarlo SM, Banks, DE, Liss, G.M, Broder I.(1997)。Outcome determinants for isocyanate induced occupational asthma among compensation claimants。
3.
Lemiere C, Malo JL, Boulet, LP, Boulet M.(1996)。Reactive airways dysfunction syndrome induced by exposure to a mixture containing isocyanate: functional and histopathologic behaviour。
4.
Mapp CE, Beghe B, Balboni A, Zamorani G, Padoan M, Jovine L, Baricordi OR, Fabbri LM.(2000)。Association between HLA genes and susceptibility to toluene diisocyanateinduced asthma。
5.
Mapp, CE, Balboni, A, Baricordi, R, and Fabbri, LM.(1997)。Human leukocyte antigen associations in occupational asthma induced by isocyanates。
6.
Beghe B, Padoan M, Moss CT, Barton SJ, Holloway JW, Holgate ST, et al.(2004)。Lack of association of HLA class I genes and TNF α-308 polymorphism in toluene diisocyanate-induced asthma。
7.
Kauffmann F, Dizier MH, et al.(1997)。Epidemiological study of the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy。
8.
Redlich CA, Homer RJ, et al.(1996)。Immunologic responses to isocyanates in sensitized asthmatic subjects。
9.
Skarping G., Dalene M, et al.(1995)。Biomarkers of exposure, antibodies, and respiratory symptoms in workers heating polyurethane glue。
10.
Rihs HP, Barbalho-Krolls T, et al.(1997)。No evidence for the influence of HLA class II in alleles in isocyanate-induced asthma。
11.
Kim SH, Oh HB, Lee KW, Shin ES, Kim CW, Hong CS, et al.(2006)。HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma?。
12.
Broberg K, Tinnerberg H, Axmon A, Warholm M, Rannug A, Littorin M.(2008)。Influence of genetic factors on toluene diisocyanaterelated symptoms: evidence from a crosssectional study。
13.
Lee F, Chiung YM, Leu YT, Chou CF, Chen GJ.(1998)。A Study of HLA Typing and WorkRelated Sensitization to Isocyanates。
14.
Jerome S, et al.(1994)。HLA class II alleles in isocyanate-induced asthma。
15.
Fabbri LM, Mapp CE, Balboni A, Baricordi R.(1995)。HLA class II molecules and asthma induced by toluene diisocyanate。
16.
Balboni A, Baricordi OR, Fabbri LM, Gandini E, Ciaccia A, Mapp CE.(1996)。Association between toluene diisocyanate-induced asthma and DQ1markers: a positive role for aspartic acid at position 57。
推文
當script無法執行時可按︰
推文
推薦
當script無法執行時可按︰
推薦
引用網址
當script無法執行時可按︰
引用網址
引用嵌入語法
當script無法執行時可按︰
引用嵌入語法
轉寄
當script無法執行時可按︰
轉寄
top
:::
相關期刊
相關論文
相關專書
相關著作
熱門點閱
1.
泡綿作業勞工健康狀況之調查研究
無相關博士論文
無相關書籍
無相關著作
1.
致命性心律不整導致猝死後裝置體內去顫器病人之調適歷程
2.
心律不整之身心護理--個案報告
QR Code