The aims of this program are to establish a Web-based electronic education system linking the Computerized Physician Order Entry system (CPOE) and to improve the compliance rate of chemotherapy education for cancer patients in hematological wards. For cancer patients chemotherapy is the primary treatment for improving health and delaying the disease's progression. Of course if not properly managed chemotherapy may threaten a cancer patient's life. After analyzing the reasons for low compliance rates, we set two indicators in this program: first, family with anti neoplastic drug side-effects and second the implementation rate of self-care at home. The thresholds were both set at 80%. From Jun. 2007 to Oct. 2007, we designed, revised, established and tested a knowledge-based patient-oriented chemotherapy education system. Then we instructed nurses how to use this system. We monitored two indicators every month from Nov. 2007 to Mar. 2008. The results showed patients' knowledge level reached 86.8%, while the implementation rate of self-care was only 79.1%. In conclusion, we hope to continue improving patients' implementation rate of self-care at home and also to share our patient-centered professional nursing experience with all other nurses.