This article describes a nursing experience in a patient with Domino Liver Transplantation in an intensive unit, being the first case in Asia and Taiwan. From December 23 to 26 in 2007, data were collected through direct care, observation, conversation, and physical examination according to Gordon's functional health assessment guide. The nursing problems identified included: risk for infection, deficient fluid volume, anxiety and knowledge deficit. The medical and nursing team used professional knowledge and skill to successfully help the patient and family coped with the postoperative acute phase. We are honored to share such a valuable experience with other professionals in the field.