背景 : 隨著醫院資訊系統廣泛的被使用，醫院資訊系統績效必須被審慎的評估。護理人員是醫院內最大的專業族群，同時也是給予病患合適照護的主要提供者，因此護理人員對於醫院資訊系統的導入與評估扮演一個關鍵角色。 目的 : 本研究主要目的為探討影響護理人員接受醫院資訊系統使用之關鍵因素。並以科技接受模式為理論基礎，加入系統品質與資訊品質、高階主管支持與專案小組技能、使用者之自我效能與相容性等六個外生變項，以建立研究架構，並依此架構進行研究工具發展。 方法 : 採用問卷調查法，以某區域醫院護理人員為對象，共發放545份問卷，回收有效問卷 501份，有效回收率91.9%。所蒐集資料再以複迴歸進行資料分析。 結　果 本研究發現，護理人員對於醫院資訊系統的認知有用主要受到高階主管支持、相容性與資訊品質的影響；而認知易用的影響因素為個人電腦自我效能、高階主管支0持、相容性與資訊品質。影響護理人員使用醫院資訊系統使用接受度之關鍵因素為其對醫院資訊系統認知有用與認知易用，整體解釋變異能力達45.1%。 結論／實務應用 : 此結果可提供醫院管理者了解護理人員對醫院資訊系統使用之重要考量，並可作為醫院系統發展之參考。

Background: Hospital information systems (HISs) are widely used in Taiwan, and HIS performance must be carefully evaluated. Nursing personnel are the largest group of staff in a hospital and are the center of care delivery; thus, they play an important role in the adoption and evaluation of HISs. Purpose: The primary objective of this study was to explore the critical factors affecting the acceptance of HISs in Taiwan from a nursing perspective. On the basis of the technology acceptance model, we used six exogenous variables (system quality, information quality, user self-efficacy, compatibility, top management support, and project team competency) as investigation factors. Methods: Survey research targeted nursing personnel in the selected case hospital as participants. A total of 545 questionnaires were sent out, and 501 were returned, indicating a valid response rate of 91.9%. Collected data were analyzed using multiple regression analysis. Results: Results indicate that user self-efficacy, top management support, compatibility, and information quality have significant impacts on perceived ease of use. In addition, top management support, compatibility, and information quality were identified as having significant impacts on perceived usefulness. Furthermore, nurses’ perceived ease of use and perceived usefulness on HISs was found to impact significantly on system acceptance, with 45.1% of the total explained variance. Conclusions/Implications for Practice: Results can help managers understand key considerations affecting HIS development and use and may be applied as a reference for system development and improvement.