In the age of yet-popularity of the Internet, the trading between businesses was generally taken through the connection of telephone and facsimile to place order and respond the order. Human operations very often caused the error of order version and inconsistency of the quantity specified in the order.The research of this paper attempts to apply the technologies of Web Services and standards of data exchange for the supply chain set up by the international organization of standardization-RosettaNet to establish a high-secure data exchange system to solve the problem of system integration crossing the system platform between businesses. The SSL mechanism is adopted to achieve the information security. Hopefully it is able to build a high-secure electronic data exchange mechanism in a supply chain system by taking this implementation, in the meanwhile to enhance the effectiveness and efficiency of trading between businesses.Through the experiment and benefit evaluation of the system, the results shown that several significant qualitative benefits may be obtained, which include constructing a secure with integrated business-to-business trading platform, saving the labor cost of development and afterward maintenance, reducing data error due to the elimination of unnecessary human duplicated data entry, and being able to establish a message monitoring and controlling mechanism. The data shown from quantitative evaluation, the significant enhancement of business performance between business trading is thus obtained as well.