Objective: The purpose of this study is to explore the effect of a two month program, involving 20 walking sessions combined with 8 health education courses, on the body weight and BMI of chronic schizophrenic patients. Methods: This study used a two groups time series design. Subjects were selected by purposive sampling methods, 62 chronic schizophrenic patients with BMI greater than 24kg/m^2 were selected from a psychiatric sanatorium in southern Taiwan and divided into an experimental group with 32 subjects and a control group with 30 subjects. The experimental group was assigned to a two month walking combined health education program. The control group participated in routine activities. A follow-up measurement the subjects' weight changes was conducted two months after the experiment. The study instruments used included demographic data sheet, weight loss results log and a weight scale, using body weight, BMI as indicators. Results: After two months of walking combined health education program, the changes in body weight in pre and post test among the experimental and control groups showed significant differences (t=3.64, p=.001; t=3.99, p＜.001); changes in BMI in the experimental group and control group showed significant differences (t=3.44, p=.002; t=3.92, p＜.001), indicating that the changes in body weight of all study subjects, regardless of weight, BMI, were significantly reduced. In addition, the follow up study two months after termination of the walking combined health education program found that the weight and BMI of the both the experimental and control groups were significantly increased. Conclusion: The results demonstrate that the two-month walking combined health education program can assist chronic schizophrenic patients to improve body weight and BMI. The results of this study can be used as a reference in the promotion of weight loss programs in psychiatric sanatorium institutions in Taiwan.