Over the last five years increased efforts have been made to develop the potential of Macao as a “City of Culture”. How to implement an alternative economic model is one of the biggest challenges of the present Government, in which the expected achievements of Cultural tourism are viewed alongside with the recent developments in the MICE Industry and the organization of official international events.Cultural policies need to be based in accurate definitions of concepts and areas, a complete inventory of all the organizations and respective roles in the Culture Sector, as well as the proper use of the available instruments for the measurement of both social and economic aspects of Culture. Inspired in the Study “2009 UNESCO Framework for Cultural Statistics, by UNESCO Institute for Statistics, a preliminary framework proposal is presented, in order to stimulate the investigation, the process of data collection and the choice of indicators, aiming for the future compilation of Macau Cultural Statistics.