The purpose of this research was to establish an information system of nursing quality indicators and explore its effectiveness. A quantitative cross-sectional design used a structured questionnaire. The Wilcoxon Signed-Rank test was used to compare the differences. The results showed that durations for completing " confirming the accuracy and completeness of the data", "statistical analysis, " improvement analysis review" and "total time" before and after using information system were 12.5,10,10,31.5 minutes and 5,5,5,19 minutes respectively, reducing 39.68% time consumption. The nurses' satisfaction rate was between 92.73% and 100%. Personal characteristics did not influence the satisfaction rate. These results may be of use for nursing administrators as a reference in monitoring information systems which measure quality control indicators.